Enzyme- and Ruthenium-Catalyzed Dynamic Kinetic Resolution of Functionalized Cyclic Allylic Alcohols

被引：22

作者：

Lihammar, Richard ^{[1
]}

Millet, Renaud ^{[1
]}

Backvall, Jan-E. ^{[1
]}

机构：

[1] Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 23期

基金：

瑞典研究理事会;

关键词：

ONE-POT SYNTHESIS; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; SECONDARY ALCOHOLS; LIPASE; RACEMIZATION; ISOMERIZATION; DYSIDIOLIDE; COMPLEXES; PALLADIUM;

D O I：

10.1021/jo402086z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective synthesis of functionalized cyclic allylic alcohols via dynamic kinetic resolution has been developed. Cyclopentadienylruthenium catalysts were used for the racemization, and lipase PS-IM or CALB was employed for the resolution. By optimization of the reaction conditions the formation of the enone byproduct was minimized, making it possible to prepare a range of optically active functionalized allylic alcohols in good yields and high ee's.

引用

页码：12114 / 12120

页数：7

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