Alterations of synaptic plasticity in aged rats: Evidence of functional and morphological studies

被引：4

作者：

Qiong Xiang ^{[1
]}

Li, Xian-Hui ^{[1
]}

Fang, Xin-Xing ^{[1
]}

Jing Jia ^{[1
]}

Jie Ren ^{[1
]}

Dong, Yu-Chun ^{[1
]}

Cheng Ou-Yang ^{[1
]}

机构：

[1] Jishou Univ, Med Res Ctr, Inst Med, Jishou, Hunan, Peoples R China

来源：

TECHNOLOGY AND HEALTH CARE | 2018年 / 26卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Aging; cognitive deficits; synaptic plasticity; hippocampal neurons; LONG-TERM POTENTIATION; ALZHEIMERS-DISEASE; RECOGNITION MEMORY; MODEL; HIPPOCAMPUS; NEUROSCIENCE; GENES; MICE;

D O I：

10.3233/THC-170978

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

BACKGROUND: The aging-related disease and associated neurodegenerative complications, such as cognitive impairment, has received increasing attention. OBJECTIVE: The aim of this study was to show changes in cognitive behavior and molecular related the synaptic plasticity in aged-induced cognitive deficits rats. METHODS: We used novel object recognition testing and morphological staining as well as western blot to detect changes in cognitive behavior and molecular related the synaptic plasticity. RESULTS: The morphological changes of synaptic structure and number on hippocampal neurons and learning and memory deficits were shown during natural aging. Moreover, learning and memory improvement was associated with alterations of hippocampal synaptic plasticity-related proteins, such as SNAP-25, synaptophysin, snapsoin-1 and so on, which distributes to cognitive decline in natural aging. CONCLUSIONS: Our study provides more behavior and molecular evidence on relationship of cognitive deficits and aging.

引用

页码：271 / 278

页数：8

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