Synergistic effect of MTHFR C677T and F2 G20210A polymorphisms on ischemic stroke

被引：6
|
作者：
They-They, Thierry Paluku [1 ,2 ]
Battas, Omar [1 ]
Nadifi, Sellama [2 ]
机构：
[1] Hassan II Univ, Fac Med, Dept Clin Neurosci & Biol Psychiat, Casablanca 10000, Morocco
[2] Hassan II Univ, Lab Genet & Mol Pathol, Fac Med, Casablanca 10000, Morocco
来源：
NEUROSCIENCE BULLETIN | 2013年 / 29卷 / 06期
关键词：
genotyping; prothrombotic polymorphisms; risk factor; MTHFR; F2; stroke; FACTOR-V-LEIDEN; METHYLENETETRAHYDROFOLATE REDUCTASE; YOUNG-ADULTS; PLASMA HOMOCYSTEINE; PROTHROMBIN G20210A; RISK-FACTOR; MYOCARDIAL-INFARCTION; COMMON MUTATION; DISEASE; GENE;
D O I：
10.1007/s12264-013-1381-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The predisposition to stroke might involve interactive effects among variants in several genes. We tested this hypothesis by examining the influence of polymorphisms in methylenetetrahydrofolate reductase (MTHFR) (C677T) and prothrombin (F2) (G20210A) as risk factors for stroke in Morocco. The polymerase chain reaction-restriction fragment length polymorphism methods were used to analyze DNA from 91 stroke patients and 182 controls. Association between the two polymorphisms and the risk of stroke was estimated by four-level models for the analysis of genetic interaction. Neither the MTHFR 677TT nor the F2 20210GA genotype showed any significant association compared to the MTHFR CC and F2 GG genotypes, respectively. An interactive effect between the MTHFR 677TT and F2 20210GA polymorphisms showed an increased risk of stroke. The odds ratios, in univariate and multivariate analysis, for the combined polymorphisms were 4.99 (95% CI, 1.75-14.2, P = 0.001) and 5.29 (95% CI, 1.63-17.1, P = 0.005), respectively.
引用
收藏
页码：725 / 730
页数：6
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