Heterogeneous Enantioselective Hydrogenation of Aromatic Ketones Catalyzed by Cinchona- and Phosphine-Modified Iridium Catalysts

被引：59

作者：

Jiang, He-yan ^{[1
]}

Yang, Chao-fen ^{[1
]}

Li, Chun ^{[1
]}

Fu, Hai-yan ^{[1
]}

Chen, Hua ^{[1
]}

Li, Rui-xiang ^{[1
]}

Li, Xian-jun ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Inst Homogeneous Catalysis, Minist Educ,Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 48期

关键词：

alkaloids; asymmetric catalysis; iridium; ketones; supported catalysts;

D O I：

10.1002/anie.200801809

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Catalyst support: The first highly enantioselective heterogeneous hydrogenation of aromatic ketones catalyzed by Ir/SiO2 stabilized with Ph3P and modified by a chiral diamine derived from a cinchona alkaloid is described (see scheme). The reaction can be employed for the reduction of a broad range of aromatic ketones to the corresponding alcohols with high enantioselectivity. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9240 / 9244

页数：5

共 72 条

[1]

Acprzak K. K., 2001, SYNTHESIS-STUTTGART, V7, P961

[2]

[Anonymous], J CHEM SOC JPN

[3]

[Anonymous], [No title captured], DOI DOI 10.1002/9783527613144.CH08

[4] Cinchona-modified platinum catalysts: From ligand acceleration to technical processes [J].