Thirty-five-year institutional experience with end-to-side repair for esophageal atresia

Hypothesis: End-to-side repair (ES) with ligation of the tracheoesophageal fistula (TEF) reduces the risks of stricture and gastroesophageal reflux disease requiring operation compared with the end-to-end repair of esophageal atresia and distal TEF. Design: Case series with institutional and historical con trol subjects. Setting: Referral children's hospital. Patients: One hundred thirty-four infants diagnosed as having esophageal atresia and distal TEF between June 30, 1968, and July 1, 2003. Interventions: Ninety-six infants having ES and 38 having end-to-end repair. Main Outcome Measures: Patients were studied for overall survival, surgical complications, and well-being during the first year of life. Results: Survival was 95% vs 90% (patients undergoing ES vs end-to-end repair). Complications included anastomotic leak, 8% vs 13%; recurrent TEF, 7% vs 3%, with only 1 recurrence in the last 28 patients having ES; anastornotic stricture (requiring dilatation), 5% vs 13%; gastroesophageal reflux disease requiring operation, 6% vs; 18%; and esophageal dysmotility, which was present following nearly all ES and end-to-end procedures. Tracheomalacia-related respiratory symptoms following ES decreased from 50% to 11% at 1 year of age. Ageappropriate diet following ES was achieved in 93% by 1 year; 5% experienced occasional dysphagia or choking episodes. Conclusions: The ES operation is accompanied by a reduced rate of stricture and gastroesophageal. reflux disease requiring operation compared with end-to-end repair. Earlier concerns regarding an unacceptable risk of recurrent TEF were not substantiated.