Biocompatibility and safety of PLA and its copolymers

被引：442

作者：

Ramot, Yuval ^{[1
]}

Haim-Zada, Moran ^{[2
]}

Domb, Abraham J. ^{[2
]}

Nyska, Abraham ^{[3
]}

机构：

[1] Hadassah Hebrew Univ, Med Ctr, IL-9112001 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Inst Drug Res, Jerusalem, Israel

[3] Tel Aviv Univ, Tel Aviv, Israel

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 107卷

关键词：

PLA; Biocompatibility; Toxicity; PLGL; Polymers; Degradable materials; FOREIGN-BODY REACTION; L-LACTIC ACID; CRUCIATE LIGAMENT RECONSTRUCTION; POLY(L-LACTIDE) BONE PLATES; IN-VIVO BIOCOMPATIBILITY; KNOTLESS SUTURE ANCHORS; HIV-INFECTED PATIENTS; POLYLACTIC ACID; BIODEGRADABLE POLYMERS; FACIAL LIPOATROPHY;

D O I：

10.1016/j.addr.2016.03.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

PLA and its copolymers are commonly used for a wide variety of applications. While they are considered to be biocompatible, side effects resulting from their implantation have been reported. The implantation of biomaterials always results in a foreign body reaction. Such a reaction has also been reported following PLA and its copolymers. This article reviews the process of inflammatory reaction that is to be expected following implantation of PLA, and it highlights specific cases in which the inflammatory reaction can result in safety concerns. The authors also review selected cases from different medical fields to demonstrate possible clinical side effects resulting from its use. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：153 / 162

页数：10

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