FERROPTOSIS Oxidized PEs trigger death

被引：144

作者：

D'Herde, Katharina ^{[1
]}

Krysko, Dmitri V. ^{[1
,2
]}

机构：

[1] Univ Ghent, Dept Basic Med Sci, Ghent, Belgium

[2] Univ Ghent, CRIG, Ghent, Belgium

来源：

NATURE CHEMICAL BIOLOGY | 2017年 / 13卷 / 01期

关键词：

LIPID-METABOLISM; CELL-DEATH;

D O I：

10.1038/nchembio.2261

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ferroptosis is characterized by accumulation of lipid peroxidation products and lethal ROS, but the source and identity of lipid death signals that cause toxicity are poorly defined. New studies reveal that ACSL4 controls sensitivity to ferroptosis and that oxidized phosphatidylethanolamines are critical for ferroptosis execution.

引用

页码：4 / 5

页数：2

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