A review of telbivudine for the management of chronic hepatitis B virus infection

被引：0
|
作者：
Lui, Yanni Y. N. [1 ,2 ]
Chan, Henry L. Y. [1 ,2 ,3 ]
机构：
[1] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Inst Digest Dis, Hong Kong, Hong Kong, Peoples R China
[3] 9F Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
来源：
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2008年 / 4卷 / 10期
关键词：
adefovir; dipivoxil; entecavir; hepatitis B; IFN; lamivudine; pharmacokinetics; telbivudine; treatment;
D O I：
10.1517/17425255.4.10.1351
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: Chronic hepatitis B is a worldwide health problem. Research interests have focused on the development of potent and safe antiviral agents with low resistance rates. Telbivudine is a nucleoside analogue that has been approved for treatment of chronic hepatitis B. Objective: This review article concentrates on the pharmacokinetics and therapeutic efficacy of telbivudine. The resistance and safety profiles are also addressed. Methods: Relevant publications were identified from searches of MEDLINE (1996 - June 2007), the Cochrane Library and BIOSIS (1993 - June 2007). Search items included, but were not limited to, telbivudine, pharmacokinetics, hepatitis B, resistance and adverse events. Conclusions: Clinical trials demonstrated telbivudine to be a safe and potent antiviral agent for treatment of chronic hepatitis B. Telbivudine has superior efficacy compared to lamivudine and adefovir.
引用
收藏
页码：1351 / 1361
页数：11
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