IgG4 anti-neurofascin 155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay

被引：64

作者：

Kadoya, Masato ^{[1
]}

Kaida, Kenichi ^{[1
]}

Koike, Haruki ^{[2
]}

Takazaki, Hiroshi ^{[1
]}

Ogata, Hidenori ^{[3
]}

Moriguchi, Kota ^{[1
]}

Shimizu, Jun ^{[4
]}

Nagata, Eiichiro ^{[5
]}

Takizawa, Shunya ^{[5
]}

Chiba, Atsuro ^{[6
]}

Yamasaki, Ryo

Kira, Jun-ichi ^{[3
]}

Sobue, Gen ^{[2
]}

Ikewaki, Katsunori ^{[1
]}

机构：

[1] Natl Def Med Coll, Dept Neurol Antiaging & Vasc Med, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan

[2] Nagoya Univ, Dept Neurol, Grad Sch Med, Nagoya, Aichi 4668550, Japan

[3] Kyushu Univ, Neurol Inst, Grad Sch Med Sci, Dept Neurol,Higashi Ku, Fukuoka 8128582, Japan

[4] Univ Tokyo, Dept Neurol, Bunkyo Ku, Tokyo 1138655, Japan

[5] Tokai Univ, Dept Neurol, Sch Med, Isehara, Kanagawa 2591193, Japan

[6] Kyorin Univ, Dept Neurol, Mitaka, Tokyo 1818611, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 301卷

关键词：

Chronic inflammatory demyelinating; polyradiculoneuropathy; Neurofascin155; IgG4; Antibody; Enzyme-linked immunosorbent assay;

D O I：

10.1016/j.jneuroim.2016.10.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We aimed to validate the diagnostic utility of enzyme-linked immunosorbent assay (ELISA) for the detection of anti-neurofascin (NF) 155 antibody in 191 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Human NF155-based ELISA clearly distinguished between anti-NF155 antibody-positive and -negative sera. Fifteen CIDP patients (8%) were IgG4 anti-human NF155 antibody-positive, which were confirmed by western blot, cell-based assay and immunohistochemical study. None of disease controls or healthy subjects had positive results. Clinical presentation of IgG4 anti-NF155 antibody-positive patients was consistent with those in previous reports. This ELISA combined with determination of the IgG4 subclass is useful in screening for anti-NF155 antibodies. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：16 / 22

页数：7

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