Mechanically Tunable, Self-Adjuvanting Nanoengineered Polypeptide Particles

被引：87

作者：

Cui, Jiwei ^{[1
]}

De Rose, Robert ^{[2
]}

Best, James P. ^{[1
]}

Johnston, Angus P. R. ^{[1
]}

Alcantara, Sheilajen ^{[2
]}

Liang, Kang ^{[1
]}

Such, Georgina K. ^{[1
]}

Kent, Stephen J. ^{[2
]}

Caruso, Frank ^{[1
]}

机构：

[1] Univ Melbourne, Dept Chem & Biomol Engn, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 25期

基金：

澳大利亚研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

vaccine delivery; nanotechnology; mesoporous silica; polypeptide particles; CpG; adjuvants; POLYMER CAPSULES; DELIVERY; NANOPARTICLES; IMMUNITY;

D O I：

10.1002/adma.201300981

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery.

引用

页码：3468 / 3472

页数：5

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