Mechanically Tunable, Self-Adjuvanting Nanoengineered Polypeptide Particles

被引：87

作者：

Cui, Jiwei ^{[1
]}

De Rose, Robert ^{[2
]}

Best, James P. ^{[1
]}

Johnston, Angus P. R. ^{[1
]}

Alcantara, Sheilajen ^{[2
]}

Liang, Kang ^{[1
]}

Such, Georgina K. ^{[1
]}

Kent, Stephen J. ^{[2
]}

Caruso, Frank ^{[1
]}

机构：

[1] Univ Melbourne, Dept Chem & Biomol Engn, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 25期

基金：

澳大利亚研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

vaccine delivery; nanotechnology; mesoporous silica; polypeptide particles; CpG; adjuvants; POLYMER CAPSULES; DELIVERY; NANOPARTICLES; IMMUNITY;

D O I：

10.1002/adma.201300981

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery.

引用

页码：3468 / 3472

页数：5

共 33 条

[11] Binding, Internalization, and Antigen Presentation of Vaccine-Loaded Nanoengineered Capsules in Blood [J].

De Rose, Robert ;

Zelikin, Alexander N. ;

Johnston, Angus P. R. ;

Sexton, Amy ;

Chong, Siow-Feng ;

Cortez, Christina ;

Mulholland, William ;

Caruso, Frank ;

Kent, Stephen J. .

ADVANCED MATERIALS, 2008, 20 (24) :4698-+

[12] Design of polymeric nanoparticles for biomedical delivery applications [J].

Elsabahy, Mahmoud ;

Wooley, Karen L. .

CHEMICAL SOCIETY REVIEWS, 2012, 41 (07) :2545-2561

[13]

Guy B, 2007, NAT REV MICROBIOL, V5, P505, DOI 10.1038/nrmicro1681

[14]

John ALS, 2012, NAT MATER, V11, P250, DOI [10.1038/NMAT3222, 10.1038/nmat3222]

[15] Challenges facing colloidal delivery systems: From synthesis to the clinic [J].

Johnston, Angus P. R. ;

Such, Georgina K. ;

Ng, Sher Leen ;

Caruso, Frank .

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2011, 16 (03) :171-181

[16] The formation of polymer vesicles or "peptosomes" by polybutadiene-block-poly(L-glutamate)s in dilute aqueous solution [J].

Kukula, H ;

Schlaad, H ;

Antonietti, M ;

Förster, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (08) :1658-1663

[17] Polymeric Materials for Gene Delivery and DNA Vaccination [J].

Nguyen, David N. ;

Green, Jordan J. ;

Chan, Juliana M. ;

Longer, Robert ;

Anderson, Daniel G. .

ADVANCED MATERIALS, 2009, 21 (08) :847-867

[18] Polymeric particles in vaccine delivery [J].

Rice-Ficht, Allison C. ;

Arenas-Gamboa, Angela M. ;

Kahl-McDonagh, Melissa M. ;

Ficht, Thomas A. .

CURRENT OPINION IN MICROBIOLOGY, 2010, 13 (01) :106-112

[19] Vaccines: From Empirical Development to Rational Design [J].

Rueckert, Christine ;

Guzman, Carlos A. .

PLOS PATHOGENS, 2012, 8 (11)

[20] A Protective Vaccine Delivery System for In Vivo T Cell Stimulation Using Nanoengineered Polymer Hydrogel Capsules [J].

Sexton, Amy ;

Whitney, Paul G. ;

Chong, Siow-Feng ;

Zelikin, Alexander N. ;

Johnston, Angus P. R. ;

De Rose, Robert ;

Brooks, Andrew G. ;

Caruso, Frank ;

Kent, Stephen J. .

ACS NANO, 2009, 3 (11) :3391-3400

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