Mechanically Tunable, Self-Adjuvanting Nanoengineered Polypeptide Particles

被引：87
作者：
Cui, Jiwei [1 ]
De Rose, Robert [2 ]
Best, James P. [1 ]
Johnston, Angus P. R. [1 ]
Alcantara, Sheilajen [2 ]
Liang, Kang [1 ]
Such, Georgina K. [1 ]
Kent, Stephen J. [2 ]
Caruso, Frank [1 ]
机构：
[1] Univ Melbourne, Dept Chem & Biomol Engn, Parkville, Vic 3010, Australia
[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia
来源：
ADVANCED MATERIALS | 2013年 / 25卷 / 25期
基金：
澳大利亚研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
vaccine delivery; nanotechnology; mesoporous silica; polypeptide particles; CpG; adjuvants; POLYMER CAPSULES; DELIVERY; NANOPARTICLES; IMMUNITY;
D O I：
10.1002/adma.201300981
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery.
引用
收藏
页码：3468 / 3472
页数：5
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