Gene expression profiling of murine T-cell lymphoblastic lymphoma identifies deregulation of S-phase initiating genes

被引：2

作者：

Dabrowska, Magdalena Julia ^{[1
,2
]}

Ejegod, Ditte ^{[1
]}

Lassen, Louise Berkhoudt ^{[1
]}

Johnsen, Hans Erik ^{[2
]}

Wabl, Matthias ^{[3
]}

Pedersen, Finn Skou ^{[1
]}

Dybkaer, Karen ^{[2
]}

机构：

[1] Aarhus Univ, Dept Mol Biol & Genet, Aarhus, Denmark

[2] Aalborg Univ Hosp, Dept Hematol, DK-9000 Aalborg, Denmark

[3] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

来源：

LEUKEMIA RESEARCH | 2013年 / 37卷 / 10期

关键词：

T-cell lymphoblastic lymphoma; T-LBL; Mouse model; Insertional mutagenesis; MLV; Gene expression Profiling; SL3-3; CANCER GENES; CYCLE; ACTIVATION; ENHANCER; SL3-3; ADOLESCENTS; APOPTOSIS; CHILDREN; MYB; INHIBITOR;

D O I：

10.1016/j.leukres.2013.04.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a search for genes and pathways implicated in T-cell lymphoblastic lymphoma (T-LBL) development, we used a murine lymphoma model, where mice of the NMRI-inbred strain were inoculated with murine leukemia virus mutants. The resulting tumors were analyzed by integration analysis and global gene expression profiling to determine the effect of the retroviral integrations on the nearby genes, and the deregulated pathways in the tumors. Gene expression profiling identified increased expression of genes involved in the minichromosome maintenance and origin of recognition pathway as well as downregulation in negative regulators of G1/S transition, indicating increased S-phase initiation in murine T-LBLs. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

引用

页码：1383 / 1390

页数：8

共 50 条

[41] CDC27 Promotes Tumor Progression and Affects PD-L1 Expression in T-Cell Lymphoblastic Lymphoma (vol 10, 488, 2020) [J].

Song, Yue ;

Song, Wei ;

Li, Zhaoming ;

Song, Wenting ;

Wen, Yibo ;

Li, Jiwei ;

Xia, Qingxin ;

Zhang, Mingzhi .

FRONTIERS IN ONCOLOGY, 2021, 10

[42] In vivo immunotoxicity of perfluorooctane sulfonate in BALB/c mice: Identification of T-cell receptor and calcium-mediated signaling pathway disruption through gene expression profiling of the spleen [J].

Lv, Qi-Yan ;

Wan, Bin ;

Guo, Liang-Hong ;

Yang, Yu ;

Ren, Xiao-Min ;

Zhang, Hui .

CHEMICO-BIOLOGICAL INTERACTIONS, 2015, 240 :84-93

[43] Calcineurin complex isolated from T-cell acute lymphoblastic leukemia (T-ALL) cells identifies new signaling pathways including mTOR/AKT/S6K whose inhibition synergize with calcineurin inhibition to promote T-ALL cell death [J].

Tosello, Valeria ;

Saccomani, Valentina ;

Yu, Jiyang ;

Bordin, Fulvio ;

Amadori, Alberto ;

Piovan, Erich .

ONCOTARGET, 2016, 7 (29) :45715-45729

[44] CNS cell type-specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation [J].

Ke, Yazi D. ;

Chan, Gabriella ;

Stefanoska, Kristie ;

Au, Carol ;

Bi, Mian ;

Mueller, Julius ;

Przybyla, Magdalena ;

Feiten, Astrid ;

Prikas, Emmanuel ;

Halliday, Glenda M. ;

Piguet, Olivier ;

Kiernan, Matthew C. ;

Kassiou, Michael ;

Hodges, John R. ;

Loy, Clement T. ;

Mattick, John S. ;

Ittner, Arne ;

Kril, Jillian J. ;

Sutherland, Greg T. ;

Ittner, Lars M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 294 (38) :14149-14162

[45] Terminal deoxynucleotidyl transferase negative T-cell lymphoblastic lymphoma from heterotopic Warthin's tumor in cervical lymph nodes: a case report and review of literature [J].

Pan, Xubo ;

Yu, Shengqiang ;

Che, Lisha ;

Xu, Junqing ;

Zhou, Huihui .

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2019, 12 (11) :4167-4170

[46] Apoptosis Induction by Polygonum minus Is Related to Antioxidant Capacity, Alterations in Expression of Apoptotic-Related Genes, and S-Phase Cell Cycle Arrest in HepG2 Cell [J].

Ghazali, Mohd Alfazari Mohd ;

Al-Naqeb, Ghanya ;

Selvarajan, Kesavanarayanan Krishnan ;

Hasan, Mizaton Hazizul ;

Adam, Aishah .

BIOMED RESEARCH INTERNATIONAL, 2014, 2014

[47] High ENT1 and DCK gene expression levels are a potential biomarker to predict favorable response to nelarabine therapy in T-cell acute lymphoblastic leukemia [J].

Akahane, Koshi ;

Murakami, Yasushi ;

Kagami, Keiko ;

Abe, Masako ;

Harama, Daisuke ;

Shinohara, Tamao ;

Watanabe, Atsushi ;

Goi, Kumiko ;

Nishi, Rie ;

Yamauchi, Takahiro ;

Kimura, Shunsuke ;

Takita, Junko ;

Look, A. Thomas ;

Minegishi, Masayoshi ;

Sugita, Kanji ;

Inukai, Takeshi .

HEMATOLOGICAL ONCOLOGY, 2019, 37 (04) :516-519

[48] Comparison of immunohistochemistry and gene expression profiling subtyping for diffuse large B-cell lymphoma in the phase III clinical trial of R-CHOP ± ibrutinib [J].

Balasubramanian, Sriram ;

Wang, Songbai ;

Major, Christopher ;

Hodkinson, Brendan ;

Schaffer, Michael ;

Sehn, Laurie H. ;

Johnson, Peter ;

Zinzani, Pier Luigi ;

Carey, Jodi ;

Shreeve, S. Martin ;

Sun, Steven ;

Gerecitano, John ;

Vermeulen, Jessica ;

Staudt, Louis M. ;

Wilson, Wyndham .

BRITISH JOURNAL OF HAEMATOLOGY, 2021, 194 (01) :83-91

[49] Cytotoxicity of inorganic mercury in murine T and B lymphoma cell lines:: involvement of reactive oxygen species, Ca2+ homeostasis, and cytokine gene expression [J].

Kim, SH ;

Sharma, RP .

TOXICOLOGY IN VITRO, 2003, 17 (04) :385-395

[50] Randomized Phase III Study of Alisertib or Investigator's Choice (Selected Single Agent) in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma [J].

O'Connor, Owen A. ;

Ozcan, Muhit ;

Jacobsen, Eric D. ;

Roncero, Josep M. ;

Trotman, Judith ;

Demeter, Judit ;

Masszi, Tamas ;

Pereira, Juliana ;

Ramchandren, Radhakrishnan ;

Beaven, Anne ;

Caballero, Dolores ;

Horwitz, Steven M. ;

Lennard, Anne ;

Turgut, Mehmet ;

Hamerschlak, Nelson ;

d'Amore, Francesco A. ;

Foss, Francine ;

Kim, Won-Seog ;

Leonard, John P. ;

Zinzani, Pier Luigi ;

Chiattone, Carlos S. ;

Hsi, Eric D. ;

Truemper, Lorenz ;

Liu, Hua ;

Sheldon-Waniga, Emily ;

Ullmann, Claudio Dansky ;

Venkatakrishnan, Karthik ;

Leonard, E. Jane ;

Shustov, Andrei R. .

JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (08) :613-+

← 1 2 3 4 5 →