Gene expression profiling of murine T-cell lymphoblastic lymphoma identifies deregulation of S-phase initiating genes

被引：2
作者：
Dabrowska, Magdalena Julia [1 ,2 ]
Ejegod, Ditte [1 ]
Lassen, Louise Berkhoudt [1 ]
Johnsen, Hans Erik [2 ]
Wabl, Matthias [3 ]
Pedersen, Finn Skou [1 ]
Dybkaer, Karen [2 ]
机构：
[1] Aarhus Univ, Dept Mol Biol & Genet, Aarhus, Denmark
[2] Aalborg Univ Hosp, Dept Hematol, DK-9000 Aalborg, Denmark
[3] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
来源：
LEUKEMIA RESEARCH | 2013年 / 37卷 / 10期
关键词：
T-cell lymphoblastic lymphoma; T-LBL; Mouse model; Insertional mutagenesis; MLV; Gene expression Profiling; SL3-3; CANCER GENES; CYCLE; ACTIVATION; ENHANCER; SL3-3; ADOLESCENTS; APOPTOSIS; CHILDREN; MYB; INHIBITOR;
D O I：
10.1016/j.leukres.2013.04.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In a search for genes and pathways implicated in T-cell lymphoblastic lymphoma (T-LBL) development, we used a murine lymphoma model, where mice of the NMRI-inbred strain were inoculated with murine leukemia virus mutants. The resulting tumors were analyzed by integration analysis and global gene expression profiling to determine the effect of the retroviral integrations on the nearby genes, and the deregulated pathways in the tumors. Gene expression profiling identified increased expression of genes involved in the minichromosome maintenance and origin of recognition pathway as well as downregulation in negative regulators of G1/S transition, indicating increased S-phase initiation in murine T-LBLs. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：1383 / 1390
页数：8
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