Solid Phase Microextraction Techniques in Determination of Biomarkers

被引：38
作者：
Hamidi, Samin [1 ]
Alipour-Ghorbani, Nastaran [2 ]
Hamidi, Aliasghar [1 ,3 ]
机构：
[1] Tabriz Univ Med Sci, Food & Drug Safety Res Ctr, Tabriz 51664, Iran
[2] Univ Tabriz, Res Lab Dendrimers & Nanopolymers, Fac Chem, Tabriz, Iran
[3] Tabriz Univ Med Sci, Dept Med Chem, Fac Pharm, Tabriz, Iran
来源：
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY | 2018年 / 48卷 / 04期
关键词：
Bioanalysis; Biomarker; Biomonitoring; Sample preparation; Solid phase microextraction; CHROMATOGRAPHY-MASS SPECTROMETRY; VOLATILE ORGANIC-COMPOUNDS; PERFORMANCE LIQUID-CHROMATOGRAPHY; IN-SITU DERIVATIZATION; POLYCYCLIC AROMATIC-HYDROCARBONS; POLYMER MONOLITH MICROEXTRACTION; MOLECULARLY IMPRINTED POLYMERS; EXHALED BREATH CONDENSATE; BAR SORPTIVE EXTRACTION; ON-FIBER-DERIVATIZATION;
D O I：
10.1080/10408347.2017.1396885
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The detection and quantification of biomarkers is gaining attention in medical research and diagnostics communities. Biomarkers cover a range from gases to biological macromolecules. Because of the nanomolar range levels of typical biomarkers in plasma, blood, urine, exhalation samples, and other biological fluids as well as complex matrix of biological media, adequate sample preparation methods should be used for quantification of biomarkers. The performance of an analytical method for biomarkers should support reproducible and accurate data. In the present paper, recent progress in well-established solid phase microextraction (SPME) methods for the clinical analysis are reviewed and discussed.
引用
收藏
页码：239 / 251
页数：13
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