Human papillomavirus reactivation following treatment of genital graft-versus-host disease

被引：14

作者：

Sri, T. ^{[1
]}

Merideth, M. A. ^{[2
,3
]}

Pulanic, T. Klepac ^{[4
,5
]}

Childs, R. ^{[6
]}

Stratton, P. ^{[5
]}

机构：

[1] Epsom & St Helier Univ Hosp NHS Trust, London, England

[2] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA

[3] NIH, Intramural Off Rare Dis, Off Director, Bethesda, MD 20892 USA

[4] Community Hlth Ctr East, Zagreb, Croatia

[5] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA

[6] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA

来源：

TRANSPLANT INFECTIOUS DISEASE | 2013年 / 15卷 / 04期

关键词：

human papillomavirus; graft-versus-host disease; immunosuppression; stem cell transplantation; genital GVHD; STEM-CELL TRANSPLANTATION; LONG-TERM SURVIVORS; LICHEN-SCLEROSUS; THERAPY;

D O I：

10.1111/tid.12098

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaginal chronic graft-versus-host disease (cGVHD) is a common complication of stem cell transplantation. Human papillomavirus (HPV) disease can reactivate after transplantation, presumably because of immune factors affecting systemic immunity, such as waning antibody titers, impaired HPV reactivation and spread has not been previously described, to our knowledge. A 30-year-old woman, 2years post transplant receiving systemic cyclosporine for cGVHD, was treated with vaginal dilators, topical corticosteroids, and estrogen for vaginal cGVHD. Colposcopy and biopsy for abnormal cytology revealed condylomatous cervicitis. Over the next 4months, while continuing dilator therapy, linear verrucous lesions developed in the vagina and vulva, and were successfully treated with laser therapy. Use of local immunosuppression and dilators for genital GVHD can enhance spread of HPV infection. Integration of HPV screening and treatment into the care of women with genital cGVHD and development of strategies to manage both conditions simultaneously are warranted.

引用

页码：E148 / E151

页数：4

共 8 条

[1] Human papillomavirus reactivation following topical tacrolimus therapy of anogenital lichen sclerosus [J].