Germline-restricted chromosome (GRC) is widespread among songbirds

被引：71

作者：

Torgasheva, Anna A. ^{[1
,2
]}

Malinovskaya, Lyubov P. ^{[1
,2
]}

Zadesenets, Kira S. ^{[1
]}

Karamysheva, Tatyana V. ^{[1
]}

Kizilova, Elena A. ^{[1
,2
]}

Akberdina, Ekaterina A. ^{[1
]}

Pristyazhnyuk, Inna E. ^{[1
]}

Shnaider, Elena P. ^{[3
]}

Volodkina, Valeria A. ^{[4
]}

Saifitdinova, Alsu F. ^{[4
]}

Galkina, Svetlana A. ^{[4
]}

Larkin, Denis M. ^{[1
,5
]}

Rubtsov, Nikolai B. ^{[1
,2
]}

Borodin, Pavel M. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Siberian Dept, Inst Cytol & Genet, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Dept Cytol & Genet, Novosibirsk 630090, Russia

[3] SibEcoCenter LLC, Novosibirsk 630009, Russia

[4] St Petersburg State Univ, Dept Genet & Biotechnol, St Petersburg 199034, Russia

[5] Univ London, Royal Vet Coll, Dept Comparat Biomed Sci, London NW1 0TU, England

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2019年 / 116卷 / 24期

基金：

俄罗斯基础研究基金会;

关键词：

avian genome; programmed DNA elimination; meiosis; Passeriformes; chromosome evolution; SYNAPTONEMAL COMPLEXES; RECOMBINATION; DIVERSITY; EVOLUTION; PIGEON; SEXES; DNA;

D O I：

10.1073/pnas.1817373116

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An unusual supernumerary chromosome has been reported for two related avian species, the zebra and Bengalese finches. This large, germline-restricted chromosome (GRC) is eliminated from somatic cells and spermatids and transmitted via oocytes only. Its origin, distribution among avian lineages, and function were mostly unknown so far. Using immunolocalization of key meiotic proteins, we found that GRCs of varying size and genetic content are present in all 16 songbird species investigated and absent from germline genomes of all eight examined bird species from other avian orders. Results of fluorescent in situ hybridization of microdissected GRC probes and their sequencing indicate that GRCs show little homology between songbird species and contain a variety of repetitive elements and unique sequences with paralogs in the somatic genome. Our data suggest that the GRC evolved in the common ancestor of all songbirds and underwent significant changes in the extant descendant lineages.

引用

页码：11845 / 11850

页数：6

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