Determination of tramadol in pharmaceutical products and biological samples using a new nanocomposite carbon paste sensor based on decorated nanographene/tramadol-imprinted polymer nanoparticles/ionic liquid

被引：52

作者：

Bagheri, Hasan ^{[1
]}

Shirzadmehr, Ali ^{[2
]}

Rezaei, Mosayeb ^{[3
]}

Khoshsafar, Hosein ^{[3
]}

机构：

[1] Baqiyatallah Univ Med Sci, Chem Injuries Res Ctr, Tehran, Iran

[2] Islamic Azad Univ, Sari Branch, Young Researchers & Elite Club, Sari, Iran

[3] Islamic Azad Univ, Hamedan Branch, Young Researchers & Elite Club, Hamadan, Iran

来源：

IONICS | 2018年 / 24卷 / 03期

关键词：

Tramadol-imprinted polymer; Potentiometric sensor; Decorated nanographene; Silver nanoparticles; Ionic liquid; CHROMATOGRAPHY-MASS SPECTROMETRY; SELECTIVE POTENTIOMETRIC SENSOR; PHASE-I METABOLITES; HUMAN PLASMA; SENSITIVE DETERMINATION; ELECTROCHEMICAL SENSOR; O-DESMETHYLTRAMADOL; ELECTRODE RESPONSE; NANOTUBES MWCNTS; MEMBRANE SENSOR;

D O I：

10.1007/s11581-017-2252-1

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In the present research, design and construction of a development potentiometric sensor based on a newly nanosensing layer for the sensitive determination of tramadol in various real samples were suggested. The proposed nanosensing layer was fabricated with the incorporation of a synthesized tramadol-imprinted polymer nanoparticles "as an efficient sensing agent" into the carbon paste matrix composed of graphite powder, decorated graphene nanosheets with silver nanoparticles, and a typically ionic liquid as the conductive pasting binder. The detection limit and the linear range of this study were found to be 2.04 x 10(-9) and 3.50 x 10(-9) to 1.00 x 10(-2) M with a Nernstian slope of 59.85 +/- 0.13 mV decade(-1), respectively. The presented modified carbon paste sensor was successfully applied for the determination of tramadol in pharmaceutical and biological samples.

引用

页码：833 / 843

页数：11

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