CD4+ T Cells at the Center of Inflammaging

被引：24

作者：

Kroemer, Guido ^{[1
,2
,3
,4
,5
]}

Laurenc, Zitvogel ^{[4
,6
,7
,8
,9
]}

机构：

[1] Sorbonne Univ, Equipe Labellisee Ligue Canc, Ctr Rech Cordeliers, Univ Paris,Inserm,U1138, Paris, France

[2] Inst Gustave Roussy, Metabol & Cell Biol Platforms, Villejuif, France

[3] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

[4] Chinese Acad Med Sci, Suzhou Inst Syst Med, Suzhou, Peoples R China

[5] Karolinska Univ Hosp, Dept Womens & Childrens Hlth, Karolinska Inst, Stockholm, Sweden

[6] Univ Paris Saclay, Fac Med, Le Kremlin Bicetre, France

[7] Gustave Roussy Comprehens Canc Inst, Villejuif, France

[8] INSERM, U1015, Villejuif, France

[9] Ctr Clin Invest Biotherapies Canc CICBT, F-1428 Villejuif, France

来源：

CELL METABOLISM | 2020年 / 32卷 / 01期

关键词：

AUTOPHAGY; METFORMIN; HALLMARKS;

D O I：

10.1016/j.cmet.2020.04.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bharath et al., 2020 report that CD4(+) T lymphocytes from aged individuals exhibit defective mitochondrial autophagy, resulting in altered redox metabolism and upregulation of TH17 cytokines, which in turn may contribute to aging-associated chronic inflammation or "inflammaging."Of note, the antiaging drug metfor-min reverses this autophagy defect and rejuvenates CD4(+) T cell function.

引用

页码：4 / 5

页数：2

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