Supramolecular metal displacement allows on-fluorescence analysis of manganese(II) in living cells

被引：33

作者：

Gruppi, Francesca ^{[1
]}

Liang, Jian ^{[1
]}

Bartelle, Benjamin B. ^{[2
,3
]}

Royzen, Maksim ^{[1
]}

Turnbull, Daniel H. ^{[2
,3
]}

Canary, James W. ^{[1
]}

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

[2] NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst Biomol Med, New York, NY 10016 USA

[3] NYU, Sch Med, Dept Radiol, New York, NY 10016 USA

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 87期

基金：

美国国家卫生研究院;

关键词：

ENHANCED MRI; FREE CALCIUM; TRANSPORTER-1; SPECTROSCOPY; INDICATORS; ISOFORMS; FURA-2; PROBE;

D O I：

10.1039/c2cc34742c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Due to the importance of Mn2+ ions in biological processes, it is of growing interest to develop protocols for analysis of Mn2+ uptake and distribution in cells. A supramolecular metal displacement assay can provide ratiometric fluorescence detection of Mn2+, allowing for quantitative and longitudinal analysis of Mn2+ uptake in living cells.

引用

收藏

页码：10778 / 10780

页数：3

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