A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells

被引：104

作者：

Icard, Philippe ^{[1
,2
,3
]}

Lincet, Hubert ^{[2
]}

机构：

[1] Ctr Lutte Canc Francois Baclesse, BioTICLA EA 4656, F-14076 Caen 05, France

[2] Univ Caen Basse Normandie, IFR ICORE 146, Unite Biol & Therapies Innovantes Canc Localement, F-14076 Caen 05, France

[3] Univ Hosp, Caen, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2012年 / 1826卷 / 02期

关键词：

Energetic metabolism; Biochemical pathways; Citrate; Phosphofructokinase; FATTY-ACID SYNTHASE; PYRUVATE-KINASE M2; MITOCHONDRIAL-DNA MUTATIONS; CARBONIC-ANHYDRASE-IX; HUMAN GASTRIC-CANCER; INDUCIBLE FACTOR HIF; ENERGY-METABOLISM; GLUCOSE-METABOLISM; AEROBIC GLYCOLYSIS; COMPLEX-I;

D O I：

10.1016/j.bbcan.2012.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer cells increase glucose uptake and reject lactic acid even in the presence of oxygen (Warburg effect). This metabolism reorients glucose towards the pentose phosphate pathway for ribose synthesis and consumes great amounts of glutamine to sustain nucleotide and fatty acid synthesis. Oxygenated and hypoxic cells cooperate and use their environment in a manner that promotes their development. Coenzymes (NAD(+), NADPH,H+) are required in abundance, whereas continuous consumption of ATP and citrate precludes the negative feedback of these molecules on glycolysis, a regulation supporting the Pasteur effect. Understanding the metabolism of cancer cells may help to develop new anti-cancer treatments. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：423 / 433

页数：11

共 223 条

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