Nanoparticles in drug delivery: Past, present and future

被引：441

作者：

Couvreur, P. ^{[1
,2
]}

机构：

[1] Univ Paris 11, Fac Pharm, UMR CNRS 8612, IFR ITEM 141, F-92296 Chatenay Malabry, France

[2] CNRS, F-92296 Chatenay Malabry, France

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2013年 / 65卷 / 01期

关键词：

Nanoparticles; Nanospheres; Nanocapsules; Polymers; Drug loading; Intracellular delivery; Drug targeting; Nanotheragnostics; Opsonization; Biodegradability; Cancer resistance; CARRIERS; NANOCAPSULES; SYSTEM;

D O I：

10.1016/j.addr.2012.04.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This opinion paper relates how nanoparticles were discovered in the seventies and how the development of biodegradable materials and nanoparticle surface functionalization has allowed new treatment strategies. The reasons why only very few nanoparticle-based medicines are on the market or in late clinical trials are discussed and some new approaches are identified. Future challenges in the nanoparticle field are also identified. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：21 / 23

页数：3

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