An effective contribution to functionalized pyridines synthesis by way of an unusual rearrangement of amidines

被引：7
作者：
Beccalli, EM
Contini, A
Trimarco, P
机构：
[1] Univ Milan, Ist Chim Organ, Fac Farm, I-20133 Milan, Italy
[2] Univ Milan, Ctr Interuniv Ric Reaz Pericicil & Sintesi Sistem, I-20133 Milan, Italy
来源：
TETRAHEDRON | 2002年 / 58卷 / 06期
关键词：
amidines; 2H-pyran-2-one; 2-pyridineacetamide; thermal rearrangement;
D O I：
10.1016/S0040-4020(01)01197-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new synthesis of 2-pyridineacetamides was developed starting from pyran-2-one N-functionalized amidines 4. Secondary amines reacted in a sealed tube with amidines 4 and, by nucleophilic attack on pyran-2-one nucleus and thermal rearrangement, afforded exclusively the 2-pyridineacetamide derivatives 6 or a mixture of amide compounds 6 and 7 depending on the substituents linked to C-alpha of the starting amidine 4. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1213 / 1221
页数：9
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