Polymorphic variants of DNMT3A and the risk of endometriosis

被引：8
|
作者：
Szczepanska, Malgorzata
Mostowska, Adrianna [1 ]
Wirstlein, Przemyslaw [1 ]
Malejczyk, Jacek [2 ]
Ploski, Rafal [3 ]
Skrzypczak, Jana
Jagodzinski, Pawel P. [1 ]
机构：
[1] Poznan Univ Med Sci, Dept Biochem & Mol Biol, PL-60781 Poznan, Poland
[2] Dept Histol & Embryol, Lublin, Poland
[3] Med Univ Warsaw, Dept Med Genet, Ctr Biostruct Res, Warsaw, Poland
来源：
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2013年 / 166卷 / 01期
关键词：
Polymorphisms; Endometriosis; Infertility; DNMT3A; SINGLE-NUCLEOTIDE POLYMORPHISMS; DNA METHYLTRANSFERASES; ABERRANT EXPRESSION; POSSIBLE MECHANISM; GENE-EXPRESSION; DOWN-REGULATION; STROMAL CELLS; INFERTILITY; WOMEN; METHYLATION;
D O I：
10.1016/j.ejogrb.2012.09.003
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: Overexpression of DNA methyltransferase 3A (DNMT3A) and aberrant methylation of various genes in eutopic endometrium have been demonstrated in women with endometriosis. We aimed to study whether DNMT3A polymorphisms could be a genetic risk factor for endometriosis and endometriosis-related infertility. Study design: We studied 5 SNPs (rs2289195, rs7590760, rs13401241, rs749131 and rs1550117) located in the DNMT3A gene in 357 women with endometriosis and 640 controls. Results: We did not observe significant differences between genotype and allele frequencies of rs2289195, rs7590760, rs13401241, rs749131 and rs1550117 SNPs in women with endometriosis, endometriosis-related infertility, and controls. The lowest p values of the trend test were observed for DNMT3A rs1550117 in endometriosis and endometriosis-related infertility (p(trend) = 0.049 and p(trend) = 0.055, respectively). Conclusions: Our results did not supply evidence for the contribution of SNPs located in DNMT3A to either endometriosis or endometriosis-related infertility. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：81 / 85
页数：5
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