Characteristics of transplanted mouse myeloproliferative disease developed after repeated injections of granulocytic colony-stimulating factor

被引：7

作者：

Bigildeev, A. E. ^{[1
]}

Sats, N. V. ^{[1
]}

Grishchuk, A. L. ^{[1
]}

Nifontova, I. N. ^{[1
]}

Svinareva, D. A. ^{[1
]}

Drize, N. J. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Hematol Res Ctr, Lab Hemopoiesis Physiol, Moscow 109801, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 145卷 / 02期

关键词：

granulocytic colony-stimulating factor; myeloproliferative disease; tumor transformation; gene expression;

D O I：

10.1007/s10517-008-0068-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Transplanted myeloproliferative disease developed in mice against the background of repeated injections of granulocytic CSF was characterized using morphological and molecular biological methods. It was demonstrated that transplanted myeloproliferative disease had a non-viral nature and is probably induced by repeated injections of granulocytic CSF. Tumor cells actively populate the liver of sick animals, which leads to their rapid death. Expression of Myc, Abl, G-CSF, and MPO genes is enhanced, which is typical of myeloid neoplastic transformation.

引用

页码：270 / 275

页数：6

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