Hypoxia-inducible factor 1 and cancer pathogenesis

被引：121

作者：

Semenza, Gregg L. ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Vasc Program, Baltimore, MD USA

[2] Johns Hopkins Univ, Sch Med, Dept Pediat Med Oncol & Radiat Oncol, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD USA

来源：

IUBMB LIFE | 2008年 / 60卷 / 09期

关键词：

angiogenesis; autophagy; cancer; glycolysis; hypoxia; mitochondria; respiration; ROS;

D O I：

10.1002/iub.93

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF-1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF-1 activates the transcription of genes that increase 02 availability by stimulating angiogenesis or that reprogram cellular metabolism to adapt to reduced 02 availability. Proof of principle studies in mouse models suggests that inhibition of HIF-1 activity may have therapeutic effects, especially in combination with other anticancer drugs. (C) 2008 IUBMB.

引用

页码：591 / 597

页数：7

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