New Strategies in Squamous Cell Carcinoma of the Lung: Identification of Tumor Drivers to Personalize Therapy

被引：28

作者：

Gold, Kathryn A.

Wistuba, Ignacio I. ^{[2
]}

Kim, Edward S. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Div Canc Med, Unit 0432, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

来源：

CLINICAL CANCER RESEARCH | 2012年 / 18卷 / 11期

关键词：

GROWTH-FACTOR RECEPTOR; PHASE-III TRIAL; ALBUMIN-BOUND PACLITAXEL; ACTIVATING MUTATIONS; PLUS CETUXIMAB; CANCER; CHEMOTHERAPY; CARBOPLATIN; SOX2; AMPLIFICATION;

D O I：

10.1158/1078-0432.CCR-11-2055

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Treatment for non-small cell lung cancer has been improving, with personalized treatment increasingly becoming a reality in the clinic. Unfortunately, these advances have largely been confined to the treatment of adenocarcinomas. Treatment options for squamous cell carcinoma (SCC) of the lung have lagged behind, partly because of a lack of understanding of the oncogenes driving SCC. Cytotoxic chemotherapy continues to be the only treatment option for many of our patients, and no genetic tests are clinically useful for patients with SCC. Recent advances in basic science have identified mutations and alterations in protein expression frequently found in SCCs, and clinical trials are ongoing to target these changes. Clin Cancer Res; 18(11); 3002-7. (C) 2012 AACR.

引用

页码：3002 / 3007

页数：6

共 61 条

[1]

[Anonymous], J CLIN ONCOL

[2] The igf-1 receptor in cancer biology [J].

Baserga, R ;

Peruzzi, F ;

Reiss, K .

INTERNATIONAL JOURNAL OF CANCER, 2003, 107 (06) :873-877

[3] SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas [J].

Bass, Adam J. ;

Watanabe, Hideo ;

Mermel, Craig H. ;

Yu, Soyoung ;

Perner, Sven ;

Verhaak, Roel G. ;

Kim, So Young ;

Wardwell, Leslie ;

Tamayo, Pablo ;

Gat-Viks, Irit ;

Ramos, Alex H. ;

Woo, Michele S. ;

Weir, Barbara A. ;

Getz, Gad ;

Beroukhim, Rameen ;

O'Kelly, Michael ;

Dutt, Amit ;

Rozenblatt-Rosen, Orit ;

Dziunycz, Piotr ;

Komisarof, Justin ;

Chirieac, Lucian R. ;

LaFargue, Christopher J. ;

Scheble, Veit ;

Wilbertz, Theresia ;

Ma, Changqing ;

Rao, Shilpa ;

Nakagawa, Hiroshi ;

Stairs, Douglas B. ;

Lin, Lin ;

Giordano, Thomas J. ;

Wagner, Patrick ;

Minna, John D. ;

Gazdar, Adi F. ;

Zhu, Chang Qi ;

Brose, Marcia S. ;

Cecconello, Ivan ;

Ribeiro, Ulysses, Jr. ;

Marie, Suely K. ;

Dahl, Olav ;

Shivdasani, Ramesh A. ;

Tsao, Ming-Sound ;

Rubin, Mark A. ;

Wong, Kwok K. ;

Regev, Aviv ;

Hahn, William C. ;

Beer, David G. ;

Rustgi, Anil K. ;

Meyerson, Matthew .

NATURE GENETICS, 2009, 41 (11) :1238-U105

[4] Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck [J].

Bonner, JA ;

Harari, PM ;

Giralt, J ;

Azarnia, N ;

Shin, DM ;

Cohen, RB ;

Jones, CU ;

Sur, R ;

Raben, D ;

Jassem, J ;

Ove, R ;

Kies, MS ;

Baselga, J ;

Youssoufian, H ;

Amellal, N ;

Rowinsky, EK ;

Ang, KK .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) :567-578

[5] Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas [J].

Cappellen, D ;

De Oliveira, C ;

Ricol, D ;

de Medina, SGD ;

Bourdin, J ;

Sastre-Garau, X ;

Chopin, D ;

Thiery, JP ;

Radvanyi, F .

NATURE GENETICS, 1999, 23 (01) :18-20

[6] Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study [J].

Cappuzzo, Federico ;

Ciuleanu, Tudor ;

Stelmakh, Lilia ;

Cicenas, Saulius ;

Szczesna, Aleksandra ;

Juhasz, Erzsebet ;

Esteban, Emilio ;

Molinier, Olivier ;

Brugger, Wolfram ;

Melezinek, Ivan ;

Klingelschmitt, Gaelle ;

Klughammer, Barbara ;

Giaccone, Giuseppe .

LANCET ONCOLOGY, 2010, 11 (06) :521-529

[7] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer [J].

Carpten, John D. ;

Faber, Andrew L. ;

Horn, Candice ;

Donoho, Gregory P. ;

Briggs, Stephen L. ;

Robbins, Christiane M. ;

Hostetter, Galen ;

Boguslawski, Sophie ;

Moses, Tracy Y. ;

Savage, Stephanie ;

Uhlik, Mark ;

Lin, Aimin ;

Du, Jian ;

Qian, Yue-Wei ;

Zeckner, Douglas J. ;

Tucker-Kellogg, Greg ;

Touchman, Jeffrey ;

Patel, Ketan ;

Mousses, Spyro ;

Bittner, Michael ;

Schevitz, Richard ;

Lai, Mei-Huei T. ;

Blanchard, Kerry L. ;

Thomas, James E. .

NATURE, 2007, 448 (7152) :439-U1

[8]

Chang YS, 2002, CLIN CANCER RES, V8, P3669

[9] Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study [J].

Ciuleanu, Tudor ;

Brodowicz, Thomas ;

Zielinski, Christoph ;

Kim, Joo Hang ;

Krzakowski, Maciej ;

Laack, Eckart ;

Wu, Yi-Long ;

Bover, Isabel ;

Begbie, Stephen ;

Tzekova, Valentina ;

Cucevic, Branka ;

Pereira, Jose Rodrigues ;

Yang, Sung Hyun ;

Madhavan, Jayaprakash ;

Sugarman, Katherine P. ;

Peterson, Patrick ;

John, William J. ;

Krejcy, Kurt ;

Belani, Chandra P. .

LANCET, 2009, 374 (9699) :1432-1440

[10] Somatic mutations of the protein kinase gene family in human lung cancer [J].

Davies, H ;

Hunter, C ;

Smith, R ;

Stephens, P ;

Greenman, C ;

Bignell, G ;

Teague, B ;

Butler, A ;

Edkins, S ;

Stevens, C ;

Parker, A ;

O'Meara, S ;

Avis, T ;

Barthorpe, S ;

Brackenbury, L ;

Buck, G ;

Clements, B ;

Cole, J ;

Dicks, E ;

Edwards, K ;

Forbes, S ;

Gorton, M ;

Gray, K ;

Halliday, K ;

Harrison, R ;

Hills, K ;

Hinton, J ;

Jones, D ;

Kosmidou, V ;

Laman, R ;

Lugg, R ;

Menzies, A ;

Perry, J ;

Petty, R ;

Raine, K ;

Shepherd, R ;

Small, A ;

Solomon, H ;

Stephens, Y ;

Tofts, C ;

Varian, J ;

Webb, A ;

West, S ;

Widaa, S ;

Yates, A ;

Brasseur, F ;

Cooper, CS ;

Flanagan, AM ;

Green, A ;

Knowles, M .

CANCER RESEARCH, 2005, 65 (17) :7591-7595

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