Highly water-dispersible PEG surface modified ultra small superparamagnetic iron oxide nanoparticles useful for target-specific biomedical applications

被引：101

作者：

Park, Ja Young ^{[1
]}

Daksha, Patel ^{[1
]}

Lee, Gang Ho ^{[1
]}

Woo, Seungtae ^{[2
]}

Chang, Yongmin ^{[2
]}

机构：

[1] Kyungpook Natl Univ, Dept Chem, Coll Nat Sci, Taegu 702701, South Korea

[2] Kyungpook Natl Univ & Hosp, Dept Diagnost Radiol, Sch Med, Taegu 702701, South Korea

来源：

NANOTECHNOLOGY | 2008年 / 19卷 / 36期

关键词：

D O I：

10.1088/0957-4484/19/36/365603

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

For the application of superparamagnetic iron oxide nanoparticles in biomedical fields for target-specific purposes, they should be ultra small in diameter. We developed a simple one-step synthesis of surface modified ultra small superparamagnetic iron oxide nanoparticles (USPIONs) with an average particle diameter of 1.7 nm in a polar organic solvent. Polyethylene glycol diacid (PEG) surface modified USPIONs synthesized in triethylene glycol were nearly monodisperse in diameter and highly water-dispersible. The PEG surface modified USPIONs were tested for use as magnetic resonance (MR) contrast agents. They had a low r(2)/r(1) relaxivity ratio of 3.4 (r(1) = 4.46 and r(2) = 15.01 mM(-1) s(-1)) and showed clear dose-dependent T-1 and T-2 map images, indicating that they will be useful as both target-specific T-1 and T-2 MR contrast agents due to their ultra small size.

引用

页数：7

共 34 条

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