Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer

被引：633
作者：
Kalyane, Dnyaneshwar [1 ]
Raval, Nidhi [1 ]
Maheshwari, Rahul [1 ]
Tambe, Vishakha [1 ]
Kalia, Kiran [1 ]
Tekade, Rakesh K. [1 ]
机构：
[1] Govt India, Minist Chem & Fertilizers, Natl Inst Pharmaceut Educ & Res NIPER Ahmedabad, Dept Pharmaceut, Opposite Air Force Stn, Gandhinagar 382355, Gujarat, India
来源：
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 98卷
关键词：
Cancer; Enhanced permeability and retention effect; Liposomes; Tumor microenvironment; Polymeric micelles; Dendrimers; POSITRON-EMISSION-TOMOGRAPHY; TUMOR-NECROSIS-FACTOR; MESOPOROUS SILICA NANOPARTICLES; MACROMOLECULAR DRUG-DELIVERY; VASCULAR-PERMEABILITY; HEME OXYGENASE-1; BREAST-CANCER; POLYMERIC NANOPARTICLES; PHOTODYNAMIC THERAPY; GOLD NANOPARTICLES;
D O I：
10.1016/j.msec.2019.01.066
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
In tumorous tissues, the absence of vasculature supportive tissues intimates the formation of leaky vessels and pores (100 nm to 2 inn in diameter) and the poor lymphatic system offers great opportunity to treat cancer and the phenomenon is known as Enhanced permeability and retention (EPR) effect. The trends in treating cancer by making use of EPR effect is increasing day by day and generate multitudes of possibility to design novel anticancer therapeutics. This review aimed to present various factors affecting the EPR effect along with important things to know about EPR effect such as tumor perfusion, lymphatic function, interstitial penetration, vascular permeability, nanoparticle retention etc. This manuscript expounds the current advances and cross-talks the developments made in the of EPR effect-based therapeutics in cancer therapy along with a transactional view of its current clinical and industrial aspects.
引用
收藏
页码：1252 / 1276
页数：25
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