Highly purified HMG versus recombinant FSH for ovarian stimulation in IVF cycles

被引:31
作者
Platteau, Peter [1 ,4 ]
Andersen, Anders Nyboe [2 ]
Loft, Anne [2 ]
Smitz, Johan
Danglas, Pascal [3 ]
Devroey, Paul
机构
[1] Vrije Univ Brussels, Ctr Reprod Med, Acad Ziekenhuis, Univ Hosp, Brussels, Belgium
[2] Rigshosp, Fertil Clin, DK-2100 Copenhagen, Denmark
[3] Ferring Pharmaceut, St Prex, Switzerland
[4] Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
关键词
highly purified HMG; IVF; LH activity; pregnancy outcome; randomized controlled trial; recombinant FSH;
D O I
10.1016/S1472-6483(10)60194-0
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The objective of this study was to compare the live birth rates resulting from ovarian stimulation with highly purified human menopausal gonadotrophin (HP-14MG), which combines FSH and human chorionic gonadotroph in -driven LH activities, or recombinant FSH (rFSH) alone in women undergoing lVF cycles. An integrated analysis was performed of the raw data from two randomized controlled trials that were highly comparable in terms of eligibility criteria and post-randomization treatment regimens with either HP-HMG or rFSH for ovarian stimulation in 1VF, following a long down-regulation protocol. All randomized subjects who received at least one dose of gonadotrophin in an lVF cycle (HP-HMG, n = 491; rFSH, n = 495) were included in the analysis. Subjects who underwent intracytoplasmic sperm injection cycles were excluded. The superiority of one goonadotrophin preparation over the other was tested using the likelihood ratio test in a logistic regression analysis. The live birth rate per cycle initiated was 26.5% (130/491) with HP-HMG and 20.8% (103/495) with rFSH (P = 0.041). The odds ratio in favour of HP-HMG was 1.36 (95% confidence interval: 1.01-1.83). Thus, the findings of this integrated analysis demonstrate that ovarian stimulation with HP-HMG, following a long down-regulation protocol, in lVF cycles results in significantly more live births than stimulation with rFSH alone.
引用
收藏
页码:190 / 198
页数:9
相关论文
共 24 条
[1]   Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial [J].
Andersen, Anders Nyboe ;
Devroey, Paul ;
Arce, Joan-Carles .
HUMAN REPRODUCTION, 2006, 21 (12) :3217-3227
[2]   Resolving methodological and clinical issues in the design of efficacy trials in assisted reproductive technologies: a mini-review [J].
Arce, JC ;
Andersen, AN ;
Collins, J .
HUMAN REPRODUCTION, 2005, 20 (07) :1757-1771
[3]   The human cumulus-oocyte complex gene-expression profile [J].
Assou, Said ;
Anahory, Tal ;
Pantesco, Veronique ;
Le Carrour, Tanguy ;
Pellestor, Franck ;
Klein, Bernard ;
Reyftmann, Lionel ;
Dechaud, Herve ;
De Vos, John ;
Hamamah, Samir .
HUMAN REPRODUCTION, 2006, 21 (07) :1705-1719
[4]   Simpson's paradox and calculation of number needed to treat from [J].
Cates C.J. .
BMC Medical Research Methodology, 2 (1) :1-4
[5]  
Chatellier G, 1996, BRIT MED J, V312, P426
[6]   THE NUMBER NEEDED TO TREAT - A CLINICALLY USEFUL MEASURE OF TREATMENT EFFECT [J].
COOK, RJ ;
SACKETT, DL .
BRITISH MEDICAL JOURNAL, 1995, 310 (6977) :452-454
[7]   What is the most relevant standard of success in assisted reproduction? No single outcome measure is satisfactory when evaluating success in assisted reproduction; both twin births and singleton births should be counted as successes [J].
Dickey, RP ;
Sartor, BM ;
Pyrzak, R .
HUMAN REPRODUCTION, 2004, 19 (04) :783-787
[8]  
Diedrich K, 2002, FERTIL STERIL, V78, P520
[9]   The role of luteinizing hormone in folliculogenesis and ovulation induction [J].
Filicori, M .
FERTILITY AND STERILITY, 1999, 71 (03) :405-414
[10]   Effects of profound suppression of luteinizing hormone during ovarian stimulation on follicular activity, oocyte and embryo function in cycles stimulated with purified follicle stimulating hormone [J].
Fleming, R ;
Lloyd, F ;
Herbert, M ;
Fenwick, J ;
Griffiths, T ;
Murdoch, A .
HUMAN REPRODUCTION, 1998, 13 (07) :1788-1792