Synthesis and Antioxidant Activity of Some New Thiazolyl-Pyrazolone Derivatives

被引：36

作者：

Gaffer, H. E. ^{[1
]}

Abdel-Fattah, S. ^{[2
]}

Etman, H. A. ^{[2
]}

Abdel-Latif, E. ^{[2
]}

机构：

[1] Natl Res Ctr, Text Res Div, Giza 12622, Egypt

[2] Mansoura Univ, Fac Sci, Dept Chem, ET-35516 Mansoura, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 01期

关键词：

SOLVENT;

D O I：

10.1002/jhet.2588

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Methyl-1-thiocarbamoyl-2-pyrazolin-5-one has been utilized as a core for the synthesis of some 1-(thiazol-2-yl)-pyrazolin-5- one derivatives through diazo-coupling reaction and/or Knoevenagel condensation followed by heterocyclization with some a-halogenated reagents such as bromoacetone, phenacyl bromide, and ethyl bromoacetate. Base prompted addition of the core compound to an equimolar amount of phenyl isothiocyanate furnished 3-methyl-4-phenylthiocarbamoyl-1-thiocarbamoyl-2-pyrazolin-5- one which undergoes heterocyclization with a-halogenated reagents at the more reactive phenylthiocarbamoyl moiety to afford the corresponding 4-(thiazol-2-yl)-1-thiocarbamoyl-2-pyrazolin-5-ones. The new synthesized thiazolyl-pyrazolone compounds were evaluated for their potential antioxidant activity by using ( ABTS Radical Cation Decolorization Assay).

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收藏

页码：331 / 340

页数：10

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