Bringing natural killer cells to the clinic: ex vivo manipulation

被引：86

作者：

Childs, Richard W. ^{[1
]}

Berg, Maria ^{[1
]}

机构：

[1] NHLBI, Sect Transplantat Immunotherapy, Hematol Branch, NIH, Bethesda, MD 20892 USA

来源：

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM | 2013年

关键词：

HEMATOPOIETIC STEM-CELLS; HUMAN NK CELLS; LARGE-SCALE; ACTIVATING RECEPTORS; GENETIC-MODIFICATION; INHIBITORY SIGNALS; ADOPTIVE TRANSFER; TUMOR-CELLS; IN-VITRO; EXPANSION;

D O I：

10.1182/asheducation-2013.1.234

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

Recently, there has been a substantial gain in our understanding of the role that natural killer (NK) cells play in mediating innate host immune responses against viruses and cancer. Although NK cells have long been known to be capable of killing cancer cells independently of antigen recognition, the full therapeutic potential of NK cell-based immunotherapy has yet to be realized. Here we review novel methods to activate and expand human NK cells ex vivo for adoptive transfer in humans, focusing on the important phenotypic and functional differences observed among freshly isolated, cytokine activated, and ex vivo-expanded NK populations.

引用

页码：234 / 246

页数：13

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