Preparation and Characterization of Zaltoprofen-Loaded Polyoxalate Microspheres for Control Release

被引：3

作者：

Kim, Kyoung Hee ^{[1
,2
]}

Lee, Cheon Jung ^{[1
,2
]}

Jo, Sun A. ^{[1
,2
]}

Lee, Jung Hwan ^{[1
,2
]}

Jong, Ji Eun ^{[1
,2
]}

Lee, Dongwon ^{[1
,2
]}

Kwon, Soon Yong

Chung, Jin Wha

Khang, Gilson ^{[1
,2
]}

机构：

[1] Chonbuk Natl Univ, Dept BIN Fus Technol, Polymer Fus Res Ctr, Jeonju 561756, South Korea

[2] Chonbuk Natl Univ, Dept PolymerNano Sci Technol, Jeonju 561756, South Korea

来源：

POLYMER-KOREA | 2013年 / 37卷 / 06期

关键词：

zaltoprofen; O/W method; polyoxalate (POX); microspheres; solvent-evaporation/extraction method; IN-VITRO RELEASE; SUSTAINED-RELEASE; ENCAPSULATION EFFICIENCY; DRUG; NANOPARTICLES; BEHAVIOR; STARCH; MICROENCAPSULATION; ANTIOXIDANT; PERFORMANCE;

D O I：

10.7317/pk.2013.37.6.702

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Zaltoprofen loaded polyoxalate (POX) microspheres were prepared by an emulsion solvent-evaporation/extraction method like oil-in-water (O/W) for sustained release of zaltoprofen. The influence of several preparation parameters such as fabrication temperature, stirring speed, intensity of the sonication, initial drug ratio, molecular weight (M-w) of POX, concentration of POX and concentration of emulsifier has been investigated on the zaltoprofen release profiles. Physicochemical properties and morphology of zaltoprofen loaded POX microspheres were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimeter (DSC) and Fourier transform infrared (FTIR). Through the analyzed results, it was demonstrated that the characteristics of the microspheres greatly affected by the prepared condition. The releases behavior of zaltoprofen was investigated for 10 days in vitro. It was confirmed that the release behavior of zaltoprofen can be controlled by the manufacturing factor of solvent-evaporation/extraction method.

引用

页码：702 / 710

页数：9

共 40 条

[1] A novel enzymatically-mediated drug delivery carrier for bone tissue engineering applications: combining biodegradable starch-based microparticles and differentiation agents [J].