Expression of Angiogenic Proteins in Tumor and Stroma Affects Survival in Patients With Gastric Cancer

被引：6

作者：

Nienhueser, Henrik ^{[1
]}

Crnovrsanin, Nerma ^{[1
]}

Nerz, Daniel ^{[1
]}

Heckler, Max ^{[1
]}

Sisic, Leila ^{[1
]}

Lasitschka, Felix ^{[2
]}

Schneider, Martin ^{[1
]}

Schmidt, Thomas ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Gen Visceral & Transplant Surg, Neuenheimer Feld 110, D-69120 Heidelberg, Germany

[2] Inst Pathol, Ludwigshafen, Germany

来源：

JOURNAL OF SURGICAL RESEARCH | 2020年 / 255卷

关键词：

Gastric cancer; Angiogenesis; Tumor microenvironment; GROWTH-FACTORS; BEVACIZUMAB; VEGF; PLACEBO; MICROENVIRONMENT; CHEMOTHERAPY; MULTICENTER; INDUCTION; THERAPY; PROFILE;

D O I：

10.1016/j.jss.2020.05.045

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Gastric cancer is one of the most frequent malignancies worldwide. Angiogenic growth factors play a crucial role in mediating the crosstalk between cancer cells and the surrounding microenvironment. In this exploratory study, we investigate the impact of angiogenic proteins within the tumor cell or stroma compartment on survival of patients with gastric cancer. Materials and methods: In 29 patients, tumor and stromal compartments were separated using laser capture microdissection. Angiogenic protein expression was measured using a bead-based immunoassay and correlated with tumor stage and overall survival. Results: Overall survival was significantly shorter in patients with a high stroma concentration of vascular endothelial growth factor (VEGF)-A (23.5 (+/- 17.6) versus 33.6 (+/- 21.0) mo; P = 0.009) and stem cell factor (22.2 (+/- 18.5) versus 33.6 (+/- 21.8) mo; P = 0.01) compared with patients with a low stroma concentration. High stromal VEGF-D showed a trend toward worse survival (26.8 (+/- 22.0) versus 37.2 (+/- 19.0) mo; P = 0.09). We did not observe any significant correlation between tumor-specific expression of angiogenic cytokines and survival. Conclusions: This translational study highlights the difference in clinical impact between tumor and stromal expression of angiogenic proteins. Compartment-specific concentrations of VEGF-A and stem cell factor affect the clinical prognosis and help to identify the best therapy for patients with gastric cancer. (C) 2020 Elsevier Inc. All rights reserved.

引用

页码：172 / 180

页数：9

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