Biomimetic Nanowire Coatings for Next Generation Adhesive Drug Delivery Systems

被引：139

作者：

Fischer, Kathleen E. ^{[1
,2
,3
]}

Aleman, Benjamin J. ^{[4
,5
,6
]}

Tao, Sarah L. ^{[7
]}

Daniels, R. Hugh ^{[8
]}

Li, Esther M. ^{[8
]}

Buenger, Mark D. ^{[1
,2
]}

Nagaraj, Ganesh ^{[1
,2
]}

Singh, Parminder ^{[1
,2
]}

Zettl, Alex ^{[4
,5
,6
]}

Desai, Tejal A. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA

[3] UCSF UCB Joint Grad Grp Bioengn, San Francisco, CA 94158 USA

[4] Math Sci Div LBNL, Berkeley, CA 94720 USA

[5] Ctr Integrated Nanomech Syst COINS, Berkeley, CA 94720 USA

[6] Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA

[7] Charles Stark Draper Lab Inc, Cambridge, MA 02139 USA

[8] Nanosys Inc, Palo Alto, CA 94304 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 02期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

ATOMIC-FORCE MICROSCOPE; SPRING CONSTANT; TOMATO LECTIN; GECKO; BIOADHESION; CANTILEVERS; CALIBRATION; NOISE; LESS;

D O I：

10.1021/nl803219f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Without bioadhesive delivery devices, complex compounds are typically degraded or cleared from mucosal tissues by the mucous layer.(1-3) While some chemically modified, microstructured surfaces have been studied in aqueous environments 4,5 adhesion due to geometry alone has not been investigated. Silicon nanowire-coated beads show significantly better adhesion than those with targeting agents under shear, and can increase the lift-off force 100-fold. We have shown that nanowire coatings, paired with epithelial physiology, significantly increase adhesion in mucosal conditions.

引用

页码：716 / 720

页数：5

共 54 条

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