Biomimetic Nanowire Coatings for Next Generation Adhesive Drug Delivery Systems

被引：139

作者：

Fischer, Kathleen E. ^{[1
,2
,3
]}

Aleman, Benjamin J. ^{[4
,5
,6
]}

Tao, Sarah L. ^{[7
]}

Daniels, R. Hugh ^{[8
]}

Li, Esther M. ^{[8
]}

Buenger, Mark D. ^{[1
,2
]}

Nagaraj, Ganesh ^{[1
,2
]}

Singh, Parminder ^{[1
,2
]}

Zettl, Alex ^{[4
,5
,6
]}

Desai, Tejal A. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA

[3] UCSF UCB Joint Grad Grp Bioengn, San Francisco, CA 94158 USA

[4] Math Sci Div LBNL, Berkeley, CA 94720 USA

[5] Ctr Integrated Nanomech Syst COINS, Berkeley, CA 94720 USA

[6] Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA

[7] Charles Stark Draper Lab Inc, Cambridge, MA 02139 USA

[8] Nanosys Inc, Palo Alto, CA 94304 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

ATOMIC-FORCE MICROSCOPE; SPRING CONSTANT; TOMATO LECTIN; GECKO; BIOADHESION; CANTILEVERS; CALIBRATION; NOISE; LESS;

D O I：

10.1021/nl803219f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Without bioadhesive delivery devices, complex compounds are typically degraded or cleared from mucosal tissues by the mucous layer.(1-3) While some chemically modified, microstructured surfaces have been studied in aqueous environments 4,5 adhesion due to geometry alone has not been investigated. Silicon nanowire-coated beads show significantly better adhesion than those with targeting agents under shear, and can increase the lift-off force 100-fold. We have shown that nanowire coatings, paired with epithelial physiology, significantly increase adhesion in mucosal conditions.

引用

页码：716 / 720

页数：5

共 54 条

[1]

AINSLIE KM, 2008, J BIOMED MAT RES A, P35501

[2]

Alberts B., 2002, Garland Science, V4th

[3] Frictional adhesion: a new angle on gecko attachment [J].

Autumn, K. ;

Dittmore, A. ;

Santos, D. ;

Spenko, M. ;

Cutkosky, M. .

JOURNAL OF EXPERIMENTAL BIOLOGY, 2006, 209 (18) :3569-3579

[4] Evidence for van der Waals adhesion in gecko setae [J].

Autumn, K ;

Sitti, M ;

Liang, YCA ;

Peattie, AM ;

Hansen, WR ;

Sponberg, S ;

Kenny, TW ;

Fearing, R ;

Israelachvili, JN ;

Full, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (19) :12252-12256

[5] Adhesive force of a single gecko foot-hair [J].

Autumn, K ;

Liang, YA ;

Hsieh, ST ;

Zesch, W ;

Chan, WP ;

Kenny, TW ;

Fearing, R ;

Full, RJ .

NATURE, 2000, 405 (6787) :681-+

[6] Lectin-mediated drug targeting: history and applications [J].

Bies, C ;

Lehr, CM ;

Woodley, JF .

ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (04) :425-435

[7] CALCULATION OF THERMAL NOISE IN ATOMIC-FORCE MICROSCOPY [J].

BUTT, HJ ;

JASCHKE, M .

NANOTECHNOLOGY, 1995, 6 (01) :1-7

[8]

CHENG H, 1995, ANAT REC, V207, P427

[9] A NONDESTRUCTIVE METHOD FOR DETERMINING THE SPRING CONSTANT OF CANTILEVERS FOR SCANNING FORCE MICROSCOPY [J].

CLEVELAND, JP ;

MANNE, S ;

BOCEK, D ;

HANSMA, PK .

REVIEW OF SCIENTIFIC INSTRUMENTS, 1993, 64 (02) :403-405

[10] Diameter-controlled synthesis of single-crystal silicon nanowires [J].

Cui, Y ;

Lauhon, LJ ;

Gudiksen, MS ;

Wang, JF ;

Lieber, CM .

APPLIED PHYSICS LETTERS, 2001, 78 (15) :2214-2216

← 1 2 3 4 5 6 →