A Newly Identified Bocavirus Species in Human Stool

被引：261

作者：

Kapoor, Amit ^{[1
,2
]}

Slikas, Elizabeth ^{[1
,2
]}

Simmonds, Peter ^{[3
]}

Chieochansin, Thaweesak ^{[3
]}

Naeem, Asif ^{[4
]}

Shaukat, Shahzad ^{[4
]}

Alam, Muhammad Masroor ^{[4
]}

Sharif, Salmaan ^{[4
]}

Angez, Mehar ^{[4
]}

Zaidi, Sohail ^{[4
]}

Delwart, Eric ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Blood Syst Res Inst, San Francisco, CA 94118 USA

[2] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

[3] Univ Edinburgh, Ctr Infect Dis, Edinburgh, Midlothian, Scotland

[4] Natl Inst Hlth, Dept Virol, Islamabad, Pakistan

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 199卷 / 02期

关键词：

POLYMERASE-CHAIN-REACTION; HUMAN PARVOVIRUS PARV4; ACUTE GASTROENTERITIS; MOLECULAR EPIDEMIOLOGY; BOVINE PARVOVIRUS; VIRUS EVOLUTION; BLOOD-DONORS; HUMAN PLASMA; CHILDREN; INFECTION;

D O I：

10.1086/595831

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viral metagenomic analysis was used to identify a previously uncharacterized parvovirus species, "HBoV2," whose closest phylogenetic relative is the human bocavirus (HBoV). HBoV2 has a genomic organization identical to that of HBoV but has only 78%, 67%, and 80% identity, respectively, with the latter's NS1, NP1, and VP1/VP2 proteins. The study used polymerase chain reaction to detect HBoV2 sequences in 5 of 98 stool samples from Pakistani children and in 3 of 699 stool samples from Edinburgh. Nearly-full-length genome sequencing revealed the presence of 3 HBoV2 genotypes and evidence of recombination between genotypes. Further studies are necessary to identify anatomical sites of HBoV2 replication and potential associations with clinical symptoms or disease.

引用

页码：196 / 200

页数：5

共 34 条

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