The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides

被引：23

作者：

Brand, Guilherme D. ^{[1
,2
]}

Santos, Raimunda C. ^{[2
]}

Arake, Luisa Mayumi ^{[1
]}

Silva, Valdelania G. ^{[2
]}

Veras, Leiz M. C. ^{[2
,3
]}

Costa, Vladimir ^{[2
,4
]}

Costa, Carlos Henrique N. ^{[4
]}

Kuckelhaus, Selma S. ^{[5
]}

Alexandre, Jose Guilherme ^{[6
]}

Feio, Maria J. ^{[6
]}

Leite, Jose Roberto S. A. ^{[2
]}

机构：

[1] EMBRAPA, Lab Espectrometria Massa, Recursos Genet & Biotecnol, BR-70770900 Brasilia, DF, Brazil

[2] Univ Fed Piaui, Nucleo Pesquisa Biodiversidade & Biotecnol, UFPI, BR-64202320 Parnaiba, PI, Brazil

[3] Univ Fed Piaui, UFPI, RENORBIO, Programa Doutorado & Biotecnol, BR-64001020 Teresina, PI, Brazil

[4] IDTNP, Lab Pesquisas Leishmanioses, BR-64001450 Teresina, PI, Brazil

[5] Univ Brasilia, UnB, Fac Med, Lab Imunol Celular,Area Patol, BR-70910900 Brasilia, DF, Brazil

[6] Univ Porto, Fac Ciencias, Dept Quim & Bioquim, REQUIMTE, P-4169007 Oporto, Portugal

来源：

MOLECULES | 2013年 / 18卷 / 06期

关键词：

antimicrobial peptides; dermaseptins; phylloseptins; Phyllomedusa; Leishmania; DERMASEPTIN; 01; LEAF FROG; AZUREA;

D O I：

10.3390/molecules18067058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimicrobial peptides (AMPs) from the dermaseptin and phylloseptin families were isolated from the skin secretion of Phyllomedusa nordestina, a recently described amphibian species from Northeastern Brazil. One dermaseptin and three phylloseptins were chosen for solid phase peptide synthesis. The antiprotozoal and antimicrobial activities of the synthetic peptides were determined, as well as their cytotoxicity in mouse peritoneal cells. AMPs are being considered as frameworks for the development of novel drugs inspired by their mechanism of action.

引用

页码：7058 / 7070

页数：13

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