Tissue engineering on the nanoscale: lessons from the heart

被引：72
作者：
Fleischer, Sharon [1 ]
Dvir, Tal [1 ]
机构：
[1] Tel Aviv Univ, Lab Tissue Engn & Regenerat Med, Dept Mol Microbiol & Biotechnol, George S Wise Fac Life Sci,Ctr Nanosci & Nanotech, IL-69978 Tel Aviv, Israel
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2013年 / 24卷 / 04期
关键词：
COLLAGEN-MIMETIC PEPTIDE; ALGINATE SCAFFOLDS; NANOFIBERS; BIOMATERIALS; FABRICATION; MATRIX; CELLS; DIFFERENTIATION; MORPHOLOGY; DELIVERY;
D O I：
10.1016/j.copbio.2012.10.016
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Recognizing the limitations of biomaterials for engineering complex tissues and the desire for closer recapitulation of the natural matrix have led tissue engineers to seek new technologies for fabricating 3-dimensional (3D) cellular microenvironments. In this review, through examples from cardiac tissue engineering, we describe the nanoscale hallmarks of the extracellular matrix that tissue engineers strive to mimic. Furthermore, we discuss the use of inorganic nanoparticles and nanodevices for improving and monitoring the performance of engineered tissues. Finally, we offer our opinion on the main challenges and prospects of applying nanotechnology in tissue engineering.
引用
收藏
页码：664 / 671
页数：8
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