Effectiveness of continuous veno-venous hemofiltration in the treatment of severe acute pancreatitis

被引：36
作者：
Chen, Xuan [1 ,2 ]
Sun, Meifang [3 ]
Mao, Xiuhong [1 ]
Liu, Xiaoxia [1 ]
Sun, Weihe [1 ]
机构：
[1] Nantong Univ, Affiliated Dongtai Hosp, Dept Intens Care Unit, 002 Kangfu West Rd, Dongtai 224200, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Nanjing 210029, Jiangsu, Peoples R China
[3] Nantong Univ, Affiliated Dongtai Hosp, Dept Nursing, Dongtai 224200, Jiangsu, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2019年 / 17卷 / 04期
关键词：
severe acute pancreatitis; continuous veno-venous hemofiltration; inflammation factors; SYSTEMIC INFLAMMATORY RESPONSE; CYTOKINES; IMPROVEMENT;
D O I：
10.3892/etm.2019.7246
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Continuous veno-venous hemofiltration (CVVH) in the treatment of severe acute pancreatitis (SAP) was investigated. A total of 60 patients with SAP treated in Affiliated Dongtai Hospital of Nantong University from October 2015 to October 2017 were enrolled in this retrospective study. Among them, 32 patients received CVVH and routine internal medicine therapy (the CVVH group), and 28 received routine internal medicine therapy (the control group). Then biochemical indexes and severity of SAP after treatment were detected to investigate the roles of CVVH and routine internal medicine therapy in treating SAP. Inflammatory factors in both the CVVH and control groups were significantly decreased after treatment (P<0.05), and CVVH could eliminate more factors. Comparison of blood biochemical indexes between the CVVH and control groups were carried out. Significant improvement was found (P<0.05) after CVVH and routine internal medicine therapy. Besides, Acute Physiology and Chronic Health Evaluation (APACHE)-II grade was significantly decreased in the CVVH group compared with that in the control group after 7 days. CVVH therapy can effectively reduce the levels of inflammatory factors in SAP patients, improve their biochemical and physiological indicators, and have high clinical application value.
引用
收藏
页码：2720 / 2724
页数：5
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