Resource allocation in utero and health in later life

被引：51

作者：

Barker, D. J. P. ^{[1
,2
]}

Lampl, M. ^{[3
]}

Roseboom, T. ^{[4
]}

Winder, N. ^{[5
]}

机构：

[1] Univ Southampton, Sch Med, Southampton, Hants, England

[2] Oregon Hlth & Sci Univ, Heart Res Ctr, Portland, OR 97201 USA

[3] Emory Univ, Ctr Study Human Hlth, Atlanta, GA 30322 USA

[4] Acad Med Ctr, Amsterdam, Netherlands

[5] Univ Southampton, Sch Med, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England

来源：

PLACENTA | 2012年 / 33卷

基金：

英国医学研究理事会;

关键词：

Fetal programming; Maternal nutrition; Placenta; Sex differences; BLOOD-PRESSURE; FETAL ORIGINS; BIRTH-WEIGHT; CARDIOVASCULAR-DISEASE; HEART-DISEASE; GROWTH; DEATH; EXPOSURE; SIZE; UNDERNUTRITION;

D O I：

10.1016/j.placenta.2012.06.009

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The way that a fetus obtains and allocates nutritional resources has profound consequences for its life-long health. Under the new developmental model for the origins of chronic disease, the causes to be identified are linked to normal variations in the processes of feto-placental development, that are associated with differences in the supply of nutrients to the baby. These differences programme the function of a few key systems that are linked to chronic disease, including the immune system, anti-oxidant defences, inflammation, and the number and quality of stem cells. There is not a separate cause for each different disease. Which chronic disease originates during development may depend more on timing than on qualitative differences in experience. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：E30 / E34

页数：5

共 40 条

[1] Sex Differences in Birth Size and Intergenerational Effects of Intrauterine Exposure to Ramadan in Saudi Arabia [J].

Alwasel, S. H. ;

Abotalib, Z. ;

Aljarallah, J. S. ;

Osmond, C. ;

Alkharaz, S. M. ;

Alhazza, I. M. ;

Harrath, A. ;

Thornburg, K. ;

Barker, D. J. P. .

AMERICAN JOURNAL OF HUMAN BIOLOGY, 2011, 23 (05) :651-654

[2] Secular increase in placental weight in Saudi Arabia [J].

Alwasel, S. H. ;

Abotalib, Z. ;

Aljarallah, J. S. ;

Osmond, C. ;

Alkharaz, S. M. ;

Alhazza, I. M. ;

Harrath, A. ;

Thornburg, K. ;

Barker, D. J. P. .

PLACENTA, 2011, 32 (05) :391-394

[3]

[Anonymous], THE CHANGING BODY

[4] Developmental origins of chronic disease [J].

Barker, D. J. P. .

PUBLIC HEALTH, 2012, 126 (03) :185-189

[5] The lifespan of men and the shape of their placental surface at birth [J].

Barker, D. J. P. ;

Osmond, C. ;

Thornburg, K. L. ;

Kajantie, E. ;

Eriksson, J. G. .

PLACENTA, 2011, 32 (10) :783-787

[6] The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood [J].

Barker, David J. P. ;

Gelow, Jill ;

Thornburg, Kent ;

Osmond, Clive ;

Kajantie, Eero ;

Eriksson, Johan G. .

EUROPEAN JOURNAL OF HEART FAILURE, 2010, 12 (08) :819-825

[7] The Prenatal Origins of Lung Cancer. II. The Placenta [J].

Barker, David J. P. ;

Thornburg, Kent L. ;

Osmond, Clive ;

Kajantie, Eero ;

Eriksson, Johan G. .

AMERICAN JOURNAL OF HUMAN BIOLOGY, 2010, 22 (04) :512-516

[8] The surface area of the placenta and hypertension in the offspring in later life [J].

Barker, David J. P. ;

Thornburg, Kent L. ;

Osmond, Clive ;

Kajantie, Eero ;

Eriksson, Johan G. .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2010, 54 (2-3) :525-530

[9]

BARKER DJP, 1989, LANCET, V2, P577

[10] Trajectories of growth among children who have coronary events as adults [J].

Barker, DJP ;

Osmond, C ;

Forsén, TJ ;

Kajantie, E ;

Eriksson, JG .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (17) :1802-1809

← 1 2 3 4 →