Clubbed [1,2,3] triazoles by fluorine benzimidazole: A novel approach to H37Rv inhibitors as a potential treatment for tuberculosis

被引：229

作者：

Gill, Charansingh ^{[1
]}

Jadhav, Ganesh ^{[1
,2
]}

Shaikh, Mohammad ^{[1
,2
]}

Kale, Rajesh ^{[1
,2
]}

Ghawalkar, Anant ^{[1
]}

Nagargoje, Deepak ^{[1
]}

Shiradkar, Mahendra ^{[3
]}

机构：

[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India

[2] Wockhardt Res Ctr, Div Med Chem, Aurangabad 431210, Maharashtra, India

[3] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Chem Biol Programm, Portland, OR 97239 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 23期

关键词：

Antitubercular activity; H37Rv strain; Antimicrobial activity; Benzimidazole; 1,2,3] Triazole;

D O I：

10.1016/j.bmcl.2008.09.096

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A Novel Clubbed [1,2,3] triazoles with. uorine benzimidazole series of H37Rv strain inhibitors, potentially useful for the treatment of tuberculosis is disclosed on the basis of promising results of preliminary antimicrobial study. Evaluation of the SAR of substitution within these series has followed the identi. cation of a range of compounds. Some of the derivatives are under further evaluation showing better considerable activity compared to rifampin. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6244 / 6247

页数：4

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