Combination of silyl carbamate and amino acid fluoride for solid-phase peptide synthesis

被引：19
作者：
Sakamoto, K
Nakahara, Y
Ito, Y
机构：
[1] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan
[2] Tokai Univ, Dept Appl Biochem, Hiratsuka, Kanagawa 2591292, Japan
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 08期
关键词：
D O I：
10.1016/S0040-4039(02)00050-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Diketopiperadine (DKP) formation is an often encountered side reaction in the synthesis of peptide having C-terminal proline ester. A novel strategy for the avoidance of this side reaction as developed. which utilizes Pfp ester of Tsoc-amino acid and Fmoc-amino acid fluoride is the second and the third amino Licid. respectively. This strategy as applied to the synthesis of 37-53 fragment of the beta-chain of human chorionic gonadotropin (hCG). (C) 2002 Elsevier Science Ltd. All rights reserved.
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收藏
页码：1515 / 1518
页数：4
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