Use of pharmacokinetic modeling to optimize direct inhibition of the "undruggable" target EWS-FLI1 of Ewing sarcoma.

被引:0
|
作者
Toretsky, Jeffrey
Hong, S. Peter
Gamble, S. Ellen
Hong, Sung-Hyeok
Kobs, Christina L.
Elsass, Karen E.
South, Natalie L.
Summer, Stephen J.
Monroe, Philip J.
Uren, Aykut
机构
[1] Georgetown Lombardi Comprehens Canc Ctr, Washington, DC USA
[2] Battelle Mem Inst, Columbus, OH 43201 USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
9575
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Pharmacokinetic modeling optimizes direct inhibition of the 'undruggable' target EWS-FLI1 of Ewing Sarcoma
    Hong, S. Peter
    Gamble, S. Ellen
    Hong, Sung-Hyeok
    Kobs, Christina L.
    Elsass, Karen E.
    South, Natalie L.
    Monroe, Philip J.
    Uren, Aykut
    Toretsky, Jeffrey A.
    CANCER RESEARCH, 2012, 72
  • [2] Pharmacokinetic modeling optimizes inhibition of the 'undruggable' EWS-FLI1 transcription factor in Ewing Sarcoma
    Hong, Sung-Hyeok
    Youbi, Sarah. E.
    Hong, S. Peter
    Kallakury, Bhaskar
    Monroe, Phillip
    Erkizan, Hayriye V.
    Barber-Rotenberg, Julie S.
    Houghton, Peter
    Uren, Aykut
    Toretsky, Jeffrey A.
    ONCOTARGET, 2014, 5 (02) : 338 - 350
  • [3] Destabilization of EWS-Fli1 protein by deubiquitinase inhibition in Ewing Sarcoma
    Wang, Shan
    Kittler, Ralf
    CANCER RESEARCH, 2017, 77
  • [4] Inhibition of the splicing of the EWS-FLI1 fusion transcript reverses EWS-FLI1 driven oncogenic expression in Ewing sarcoma
    Grohar, Patrick J.
    Kim, Suntae
    Haddock, Sara
    Rivera, Guillermo Rangel
    Harlow, Matt
    Maloney, Nichole K.
    Huppi, Konrad
    Gehlhaus, Kristen
    Grandin, Magdalena
    Klumpp-Thomas, Carleen
    Buehler, Eugen
    Helman, Lee J.
    Martin, Scott E.
    Caplen, Natasha J.
    CANCER RESEARCH, 2015, 75
  • [5] Targeted Therapy for EWS-FLI1 in Ewing Sarcoma
    Gong, Helong
    Xue, Busheng
    Ru, Jinlong
    Pei, Guoqing
    Li, Yan
    CANCERS, 2023, 15 (16)
  • [6] Functional validation of CEBPB as an oncogenic target of EWS-FLI1 in Ewing sarcoma
    Abegglen, Lisa M.
    Gardiner, Jamie D.
    Mason, Clinton C.
    Carter, Bryce E.
    Schackmann, Elizabeth A.
    Stuck, Marcus
    Putnam, Angelica R.
    Randall, R. Lor
    Kovar, Heinrich
    Lessnick, Stephen L.
    Schiffman, Joshua D.
    CANCER RESEARCH, 2015, 75
  • [7] PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis
    Ogan D Abaan
    Amy Levenson
    Osman Khan
    Priscilla A Furth
    Aykut Üren
    Jeffrey A Toretsky
    Oncogene, 2005, 24 : 2715 - 2722
  • [8] PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis
    Abaan, OD
    Levenson, A
    Khan, O
    Furth, PA
    Üren, A
    Toretsky, JA
    ONCOGENE, 2005, 24 (16) : 2715 - 2722
  • [9] Targeting the EWS-FLI1 transcription factor in Ewing sarcoma
    Tancredi, R.
    Zambelli, A.
    DaPrada, G. A.
    Fregoni, V.
    Pavesi, L.
    Riccardi, A.
    Burdach, S.
    Grohar, P. J.
    D'Incalci, M.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2015, 75 (06) : 1317 - 1320
  • [10] EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin
    Siligan, C
    Ban, J
    Bachmaier, R
    Spahn, L
    Kreppel, M
    Schaefer, KL
    Poremba, C
    Aryee, DNT
    Kovar, H
    ONCOGENE, 2005, 24 (15) : 2512 - 2524