The Genetic Risk of Kidney Disease in Type 2 Diabetes

被引：34
作者：
Pezzolesi, Marcus G. [1 ,2 ]
Krolewski, Andrzej S. [1 ,2 ]
机构：
[1] Joslin Diabet Ctr, Sect Genet & Epidemiol, Div Res, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
来源：
MEDICAL CLINICS OF NORTH AMERICA | 2013年 / 97卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Type; 2; diabetes; Diabetic nephropathy; Kidney disease; Genetic risk; STAGE RENAL-DISEASE; URINARY ALBUMIN EXCRETION; GLOMERULAR-FILTRATION-RATE; GENOME-WIDE SCAN; FAMILIAL PREDISPOSITION; SUSCEPTIBILITY GENES; AFRICAN-AMERICANS; LEUCINE REPEAT; PIMA-INDIANS; LINKAGE SCAN;
D O I：
10.1016/j.mcna.2012.10.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this review, the authors discuss the major approaches being used to identify diabetic nephropathy (DN) susceptibility genes in type 2 diabetes (12D) and highlight the salient findings from studies whereby these approaches have been implemented. The recent advent of next-generation sequencing technology is beginning to impact DN gene mapping strategies. As the field moves forward, family based approaches should greatly facilitate efforts to identify variants in genes that have a major effect on the risk of DN in T2D. To be successful, the ascertainment and comprehensive study of families with multiple affected members is critical.
引用
收藏
页码：91 / +
页数：18
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