Synthesis and cytotoxicity of some novel 21E-benzylidene steroidal derivatives

被引：19

作者：

Fan, Ning-Juan ^{[1
]}

Bai, Yu-Bin ^{[1
]}

Zhang, Fei-Yu ^{[1
]}

Luo, Bo ^{[1
]}

Tang, Jiang-Jiang ^{[1
]}

Zhang, Qiang-Zhe ^{[2
]}

Gao, Jin-Ming ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Sci, Shaanxi Engn Ctr Bioresource Chem & Sustainable U, Yangling 712100, Shaanxi, Peoples R China

[2] Nankai Univ, Ctr Chem Genom & Med Technol, Tianjin 300071, Peoples R China

来源：

STEROIDS | 2013年 / 78卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Progesterone; Aldol reaction; Benzylidene steroidal derivatives; Cytotoxicity; ANTICANCER ACTIVITIES; CHALCONE DERIVATIVES; ANTIFUNGAL; ANALOGS;

D O I：

10.1016/j.steroids.2013.04.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel derivatives of 21E-benzylidene-pregn-1,4-diene-3,20-dione 7a-g and 21E-benzylidene-4-chloro-pregn-1,4-diene-3,20-dione 8a-g was synthesized from the commercially available progesterone. These title compounds were evaluated for their cytotoxic activity against brine shrimp (Artemia salina) and murine Lewis lung carcinoma cells (LLC). It was found that compounds 7a-g exhibited stronger activities than 8a-g against the brine shrimps, and some of the tested compounds possessed weak inhibition of LLC cells. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：874 / 879

页数：6

共 31 条

[1] ANTICANCER AND ANTIOXIDANT ACTIVITY OF SYNTHETIC CHALCONES AND RELATED-COMPOUNDS [J].