Different evolutionary rates and epidemic growth of hepatitis B virus genotypes A and D

被引：41

作者：

Zehender, Gianguglielmo ^{[1
]}

De Maddalena, Chiara ^{[1
]}

Giambelli, Camilla ^{[1
]}

Milazzo, Laura ^{[1
]}

Schiavini, Monica ^{[2
]}

Bruno, Raffaele ^{[3
]}

Tanzi, Elisabetta ^{[4
]}

Galli, Massimo ^{[1
]}

机构：

[1] Univ Milan, Dept Clin Sci Luigi Sacco, Infect Dis Sect, I-20157 Milan, Italy

[2] Luigi Sacco Hosp, Dept Infect Dis 2, I-20157 Milan, Italy

[3] Univ Pavia, IRCCS San Matteo Hosp, Div Infect & Trop Dis, I-27100 Pavia, Italy

[4] Univ Milan, Dept Publ Hlth Microbiol Virol, I-20133 Milan, Italy

来源：

VIROLOGY | 2008年 / 380卷 / 01期

关键词：

HBV; molecular epidemiology; coalescent; basic reproductive number; molecular evolution;

D O I：

10.1016/j.virol.2008.07.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The epidemiological history of HBV genotypes A and D and subgenotypes A2 and D3 was studied on 132 isolates drawn between 1980 and 2005 from patients living in a homogenous geographical area. Evolutionary rates and divergence dates were estimated and HBV demographic history was reconstructed by using a statistical approach based an coalescent theory. The evolutionary rate of A2 was significantly lower than that of D3. The growth rate of D3 epidemic was significantly faster than that of A2; both subgenotypes showed a decreasing growth rate from the mid-1980s. Our data suggest that the important discrepancies observed in the evolutionary rates of HBV genotypes A and D may reflect different population dynamics of their epidemics. These results show the usefulness of phylodynamic studies in reconstructing the history of epidemics due to highly variable DNA viruses, and in evaluating the long-term efficacy of prophylactic measures. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：84 / 90

页数：7

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