Chiral separation of ibuprofen and terbutaline by nonaqueous capillary electrophoresis with conductance detection

被引:0
作者
Deng, GH
Wei, SL
Mo, JY
机构
[1] Guangxi Univ Nationalities, Dept Chem, Nanning, Peoples R China
[2] Zhongshan Univ, Dept Chem, Guangzhou 510275, Peoples R China
关键词
nonaqueous medium; capillary electrophoresis with conductance detection; sulfonyl beta-CD; resolution; N; N-Dimethylformamide;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In the nonaqueous N, N-dimethylformamide medium, the chiral drugs ibuprofen and terbutaline were successfully separated with sulfonyl-beta-cyclodextrin (s-beta-CD) as the chiral selector by capillary electrophoresis with conductance detection. The comparison of the effects of three CDS(beta-CD, diethylic-beta-CD, sulfonyl-beta-CD) on the chiral separation was made and the resolution mechanism was proposed.
引用
收藏
页码:16 / 19
页数:4
相关论文
共 50 条
[41]   CHIRAL SEPARATIONS USING HEPARIN AND POLYELECTROLYTE MULTILAYERS IN CAPILLARY ELECTROPHORESIS [J].
Currie, C. A. ;
Woods, C. D. ;
Stanley, F. E. ;
Stalcup, A. M. .
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2014, 37 (15) :2218-2231
[42]   Use of various β-cyclodextrin derivatives as chiral selectors for the enantiomeric separation of ofloxacin and its five related substances by capillary electrophoresis [J].
Zhu, Bolin ;
Xu, Shuying ;
Guo, Xingjie ;
Wei, Lan ;
Yu, Jia ;
Wang, Tiejie .
JOURNAL OF SEPARATION SCIENCE, 2017, 40 (08) :1784-1795
[43]   Simultaneous Chiral Separation of Four H1-Antihistamines by Capillary Zone Electrophoresis Using a Dual Cyclodextrin System [J].
Szabo, Zoltan-Istvan ;
Toth, Csaba ;
Hancu, Gabriel ;
Muntean, Daniela-Lucia .
CHROMATOGRAPHIA, 2015, 78 (21-22) :1377-1384
[44]   Optimization of ascorbic and uric acid separation in human plasma by free zone capillary electrophoresis ultraviolet detection [J].
Zinellu, A ;
Carru, C ;
Sotgia, S ;
Deiana, L .
ANALYTICAL BIOCHEMISTRY, 2004, 330 (02) :298-305
[45]   Chiral metal-ion complexes for enantioseparation by capillary electrophoresis and capillary electrochromatography: A selective review [J].
Schmid, M. G. .
JOURNAL OF CHROMATOGRAPHY A, 2012, 1267 :10-16
[46]   Separation and determination of cefotaxime enantiomers in injection by capillary zone electrophoresis [J].
Wang, Rong ;
Jia, Zheng-Ping ;
Fan, Jun-Jie ;
Jun, Ma ;
Hua, Xie ;
Zhang, Qiang ;
Wang, Juan .
PHARMAZIE, 2009, 64 (03) :156-160
[47]   Analysis of Chiral Secondary Aromatic Alcohols by Capillary Electrophoresis Using Sulfated β-Cyclodextrin as Chiral Selector [J].
Liu Peng ;
He Wei ;
Qin Xiang-Yang ;
Wang Qiao-Feng ;
Li Xiao-Ye ;
Zhang Sheng-Yong .
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2009, 37 (08) :1167-1172
[48]   When a truck becomes a motorcycle: The impact of sample load on a chiral capillary electrophoresis separation using mixtures of neutral and sulfated cyclodextrins [J].
Nussbaum, MA .
ELECTROPHORESIS, 1999, 20 (13) :2664-2669
[49]   SEPARATION OF NON-NATURAL AMIDE AMINO ACID ENANTIOMERS BY CAPILLARY ELECTROPHORESIS WITH CM-β-CDs AS CHIRAL SELECTIVE REAGENT [J].
Yang, Xiao-Dan ;
Li, Bao-Hui .
OXIDATION COMMUNICATIONS, 2016, 39 (2A) :1875-1884
[50]   Investigation of isomerization of dexibuprofen in a ball mill using chiral capillary electrophoresis [J].
Urlaub, Jonas ;
Kaiser, Reinhard P. ;
Scherf-Clavel, Oliver ;
Bolm, Carsten ;
Holzgrabe, Ulrike .
ELECTROPHORESIS, 2021, 42 (17-18) :1790-1799