The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

被引：48

作者：

Verity, Robert ^{[1
]}

Aydemir, Ozkan ^{[2
]}

Brazeau, Nicholas F. ^{[3
]}

Watson, Oliver J. ^{[1
]}

Hathaway, Nicholas J. ^{[4
]}

Mwandagalirwa, Melchior Kashamuka ^{[5
]}

Marsh, Patrick W. ^{[2
]}

Thwai, Kyaw ^{[3
]}

Fulton, Travis ^{[6
]}

Denton, Madeline ^{[6
]}

Morgan, Andrew P. ^{[6
]}

Parr, Jonathan B. ^{[6
]}

Tumwebaze, Patrick K. ^{[7
]}

Conrad, Melissa ^{[8
]}

Rosenthal, Philip J. ^{[8
]}

Ishengoma, Deus S. ^{[9
]}

Ngondi, Jeremiah ^{[10
]}

Gutman, Julie ^{[11
]}

Mulenga, Modest ^{[12
]}

Norris, Douglas E. ^{[13
]}

Moss, William J. ^{[14
]}

Mensah, Benedicta A. ^{[15
]}

Myers-Hansen, James L. ^{[15
]}

Ghansah, Anita ^{[15
]}

Tshefu, Antoinette K. ^{[5
]}

Ghani, Azra C. ^{[1
]}

Meshnick, Steven R. ^{[3
]}

Bailey, Jeffrey A. ^{[2
]}

Juliano, Jonathan J. ^{[3
,6
,16
]}

机构：

[1] Imperial Coll London, Dept Infect Dis Epidemiol, Med Res Council, Ctr Global Infect Dis Anal, London, England

[2] Brown Univ, Warren Alpert Med Sch, Dept Pathol & Lab Med, Providence, RI 02912 USA

[3] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA

[4] Univ Massachusetts, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA

[5] Hop Gen Prov Reference Kinshasa, Kinshasa Sch Publ Hlth, Kinshasa, DEM REP CONGO

[6] Univ N Carolina, Sch Med, Div Infect Dis, Dept Med, Chapel Hill, NC 27515 USA

[7] Infect Dis Res Collaborat, Kampala, Uganda

[8] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[9] Natl Inst Med Res, Tanga, Tanzania

[10] RTI Int, Dar Es Salaam, Tanzania

[11] CDC, Malaria Branch, Ctr Global Hlth, Atlanta, GA 30333 USA

[12] Trop Dis Res Ctr, Ndola, Zambia

[13] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA

[14] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[15] Univ Ghana, Noguchi Mem Inst Med Res, Accra, Ghana

[16] Univ N Carolina, Sch Med, Curriculum Genet & Mol Biol, Chapel Hill, NC 27515 USA

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

F-STATISTICS; R PACKAGE; DIVERSITY; FRAMEWORK; SELECTION; MALARIA; REHH;

D O I：

10.1038/s41467-020-15779-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC and samples from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool. We identify an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimethamine. Furthermore, we identify highly related parasites over large geographic distances, indicative of gene flow and migration. Our results are consistent with a background of isolation by distance combined with the effects of selection for antimalarial drug resistance. This study provides a high-resolution view of parasite genetic structure across a large country in Africa and provides a baseline to study how implementation programs may impact parasite populations. The genome of the malaria parasite Plasmodium falciparum contains a record of past evolutionary forces. Here, using 2537 parasite sequences from the Democratic Republic of the Congo, the authors demonstrate how drug pressure and human movement have shaped the present-day parasite population.

引用

页数：10

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