Modulation of chromatin function through linker histone H1 variants

被引:23
|
作者
Kowalski, Andrzej [1 ]
Palyga, Jan [1 ]
机构
[1] Jan Kochanowski Univ, Dept Biochem & Genet, Inst Biol, PL-25406 Kielce, Poland
关键词
Chromatin structure; Histone H1 variants; Posttranslational modifications; Polymorphism; Protein dynamics; AMINO-ACID-SEQUENCE; GENE-EXPRESSION; POSTTRANSLATIONAL MODIFICATIONS; SECONDARY STRUCTURE; TERMINAL DOMAIN; PHOSPHORYLATION SITE; INTERACTION SURFACE; SOMATIC SUBTYPES; IN-VIVO; BINDING;
D O I
10.1111/boc.201600007
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In this review, the structural aspects of linker H1 histones are presented as a background for characterization of the factors influencing their function in animal and human chromatin. The action of H1 histone variants is largely determined by dynamic alterations of their intrinsically disordered tail domains, posttranslational modifications and allelic diversification. The interdependent effects of these factors can establish dynamic histone H1 states that may affect the organization and function of chromatin regions.
引用
收藏
页码:339 / 356
页数:18
相关论文
共 50 条