Lung cancer surgery inHIV-infected patients: An analysis of postoperative complications and long-term survival

被引:13
作者
Wang, Lin [1 ]
Chen, Yongfang [2 ]
Wang, Yifei [1 ]
Liu, Jianjian [3 ]
Wen, Zilu [1 ,5 ]
Chen, Hui [1 ]
Zhu, Yijun [1 ]
Wang, Jun [1 ]
Wan, Laiyi [1 ]
Li, Feng [4 ]
Song, Yanzheng [1 ]
机构
[1] Shanghai Publ Hlth Clin Ctr, Dept Thorac Surg, Caolanggong Rd, Shanghai 2901, Peoples R China
[2] Shanghai Publ Hlth Clin Ctr, Dept Pharm, Shanghai, Peoples R China
[3] Shanghai Publ Hlth Clin Ctr, Dept Ultrason Room, Shanghai, Peoples R China
[4] Shanghai Publ Hlth Clin Ctr, Dept Expt Anim, Caolanggong Rd, Shanghai 2901, Peoples R China
[5] Shanghai Publ Hlth Clin Ctr, Dept Sci Res, Shanghai, Peoples R China
关键词
Human immunodeficiency virus; non-small cell lung cancer; surgery; surgical outcomes; HUMAN-IMMUNODEFICIENCY-VIRUS; SWISS HIV COHORT; PROGNOSTIC-FACTOR; MORTALITY; RISK; INDIVIDUALS; POPULATION; DIAGNOSIS; MORBIDITY; SMOKING;
D O I
10.1111/1759-7714.13519
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background The purpose of this study was to investigate the risk factors of postoperative complications and reliable prognostic factors of long-term survival in HIV-infected patients with non-small cell lung cancer (NSCLC). Methods HIV-infected patients with NSCLC who underwent surgical treatment were retrospectively studied; a single-institutional analysis was conducted from November 2011 to August 2018. Pre- and postoperative clinical data, including age, gender, smoking history, highly active antiretroviral therapy (HAART), CD4+ T cell count, HIV viral load, cancer histology, clinical and pathological stage (p-stage), surgical result, Glasgow Prognostic Score (GPS), the Charlson comorbidity index (CCI), survival time and postoperative complications were collected. Results A total of 33 HIV-infected patients with NSCLC were enrolled of which 18 (54.7%) had preoperative comorbidities and postoperative complications were observed in 22 (66.7%) patients. Thirty-day mortality was not observed in these patients. Median survival time after surgery was 65 months: the MST of p-stage I patients was 65 months; p-stage II MST was unestimable; p-stage III MST was 21 months. Univariate analyses showed that postoperative complications were associated with HIV viral load (P= 0.002), CCI (P= 0.027), HAART (P= 0.028) and CD4+ T cell count (P= 0.045). However, multiple logistic regression analysis showed no correlation between HAART and postoperative complications. The p-stage was an independent prognostic factor for survival time. Conclusions In our single-arm retrospective analysis, the risk factors for postoperative complications in HIV-infected patients with NSCLC were HIV viral load, CCI and CD4+ T cell counts. The p-stage was a predictive factor for long-term survival.
引用
收藏
页码:2146 / 2154
页数:9
相关论文
共 27 条
[1]   Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening [J].
Aberle, Denise R. ;
Adams, Amanda M. ;
Berg, Christine D. ;
Black, William C. ;
Clapp, Jonathan D. ;
Fagerstrom, Richard M. ;
Gareen, Ilana F. ;
Gatsonis, Constantine ;
Marcus, Pamela M. ;
Sicks, JoRean D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (05) :395-409
[2]   Survival after cancer diagnosis in persons with AIDS [J].
Biggar, RJ ;
Engels, EA ;
Ly, S ;
Kahn, A ;
Schymura, MJ ;
Sackoff, J ;
Virgo, P ;
Pfeiffer, RM .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2005, 39 (03) :293-299
[3]   Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: Implications for patient care [J].
Brock, Malcolm V. ;
Hooker, Craig M. ;
Engels, Eric A. ;
Moore, Richard D. ;
Gillison, Maura L. ;
Alberg, Anthony J. ;
Keruly, Jeanne C. ;
Yang, Stephen C. ;
Heitmiller, Richard F. ;
Baylin, Stephen B. ;
Herman, James G. ;
Brahmer, Julie R. .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2006, 43 (01) :47-55
[4]   Lung cancer in HIV infected patients:: facts, questions and challenges [J].
Cadranel, J. ;
Garfield, D. ;
Lavole, A. ;
Wislez, M. ;
Milleron, B. ;
Mayaud, C. .
THORAX, 2006, 61 (11) :1000-1008
[5]   A NEW METHOD OF CLASSIFYING PROGNOSTIC CO-MORBIDITY IN LONGITUDINAL-STUDIES - DEVELOPMENT AND VALIDATION [J].
CHARLSON, ME ;
POMPEI, P ;
ALES, KL ;
MACKENZIE, CR .
JOURNAL OF CHRONIC DISEASES, 1987, 40 (05) :373-383
[6]   Results of Initial Low-Dose Computed Tomographic Screening for Lung Cancer [J].
Church, Timothy R. ;
Black, William C. ;
Aberle, Denise R. ;
Berg, Christine D. ;
Clingan, Kathy L. ;
Duan, Fenghai ;
Fagerstrom, Richard M. ;
Gareen, Ilana F. ;
Gierada, David S. ;
Jones, Gordon C. ;
Mahon, Irene ;
Marcus, Pamela M. ;
Sicks, JoRean D. ;
Jain, Amanda ;
Baum, Sarah .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (21) :1980-1991
[7]   Lung cancer in the Swiss HIV Cohort Study: role of smoking, immunodeficiency and pulmonary infection [J].
Clifford, G. M. ;
Lise, M. ;
Franceschi, S. ;
Egger, M. ;
Bouchardy, C. ;
Korol, D. ;
Levi, F. ;
Ess, S. ;
Jundt, G. ;
Wandeler, G. ;
Fehr, J. ;
Schmid, P. ;
Battegay, M. ;
Bernasconi, E. ;
Cavassini, M. ;
Calmy, A. ;
Keiser, O. ;
Schoeni-Affolter, F. .
BRITISH JOURNAL OF CANCER, 2012, 106 (03) :447-452
[8]   Cancer risk in the swiss HIV cohort study: Associations with immunodeficiency, smoking, and highly active antiretroviral therapy [J].
Clifford, GM ;
Polesel, J ;
Rickenbach, M ;
Dal Maso, L ;
Keiser, O ;
Kofler, A ;
Rapiti, E ;
Levi, F ;
Jundt, G ;
Fisch, T ;
Bordoni, A ;
De Weck, D ;
Franceschi, S .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (06) :425-432
[9]  
Coghill AE, 2017, CANCER EPIDEM BIOMAR, V26, P1027, DOI [10.1158/1055-9965.epi-16-0964, 10.1158/1055-9965.EPI-16-0964]
[10]   Cancer risk in people infected with human immunodeficiency virus in the United States [J].
Engels, Eric A. ;
Biggar, Robert J. ;
Hall, H. Irene ;
Cross, Helene ;
Crutchfield, Allison ;
Finch, Jack L. ;
Griggs, Rebecca ;
Hylton, Tara ;
Pawlish, Karen S. ;
McNeel, Timothy S. ;
Goedert, James J. .
INTERNATIONAL JOURNAL OF CANCER, 2008, 123 (01) :187-194